{"doi":"10.15252/embr.202357927","title":"Hematopoiesis: a BETter understanding","abstract":null,"journal":"The EMBO Reports","year":2023,"id":608138,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1561738,"name":"Peter D Adams","orcid":null,"position":1,"is_corresponding":false},{"id":549952,"name":"Nirmalya Dasgupta","orcid":"0000-0002-0289-5712","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hematopoiesis: a BETter understanding","abstract":"Epigenetic modifications are known to be crucial for hematopoietic stem cell (HSC) differentiation, with the BET family member BRD4 playing a vital role in this as an epigenetic reader. In this issue of EMBO reports, Yang et al (2023) demonstrate that the absence of BRD4 leads to senescence in HSCs and hematopoietic progenitor cells (HPCs), affecting the expression of crucial genes involved in myeloid and erythroid development. These data suggest that BRD4 has a protective role in preserving histone tails, thereby sustaining normal HSC/HPC functions.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37650879","pmcid":"PMC10561162","openalex_id":"https://openalex.org/W4386305700","authors":[],"funders":[],"total_grants":0,"fwci":0.2801,"citation_percentile":0.50796916,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10561162/pdf/EMBR-24-e57927.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10561162/pdf/EMBR-24-e57927.pdf","host_type":"repository"},{"url":"https://link.springer.com/content/pdf/10.15252/embr.202357927.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.15252/embr.202357927/fulltext.html","host_type":"publisher"},{"url":"https://www.embopress.org/doi/pdf/10.15252/embr.202357927","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10561162","host_type":"repository"},{"url":"https://doi.org/10.15252/embr.202357927","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37650879","host_type":"repository"}],"fields_of_study":["Protein Degradation and Inhibitors","Epigenetics and DNA Methylation","Acute Myeloid Leukemia Research"],"mesh_terms":["Bromodomain Containing Proteins","Animals","Cell Differentiation","Hematopoiesis","Hematopoietic Stem Cells","Histones","Humans","Transcription Factors","Cellular Senescence","Cell Cycle Proteins","Epigenesis, Genetic"],"keywords":["Epigenetics","Haematopoiesis","Histone","Biology","Cell biology","Stem cell","Progenitor cell","Myeloid","Hematopoietic stem cell","BRD4","Senescence","Genetics","Gene","Cancer research","Bromodomain"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:34:10.191613Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}