{"doi":"10.15252/embr.202255506","title":"KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization","abstract":"Abstract N 6 ‐methyladenosine (m 6 A), the most abundant internal modification in eukaryotic mRNA, plays important roles in many physiological and pathological processes, including the development and progression of cancer. RNA modification by m 6 A is regulated by methyltransferases, demethylases, and m 6 A‐binding proteins that function in large part by regulating mRNA expression and function. Here, we investigate the expression of m 6 A regulatory proteins in breast cancer. We find that expression of KIAA1429/VIRMA, a component of the m 6 A methyltransferase complex, is upregulated in breast cancer tissue and correlates positively with poor survival. KIAA1429/VIRMA is mislocalized to the cytosol of breast cancer tissues and cell lines, and shRNA‐mediated knockdown inhibits breast cancer cell proliferation, migration, and invasion. Mechanistically, KIAA1429/VIRMA is shown to bind to the m 6 A‐dependent RNA‐binding protein insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3), leading to recruitment and stabilization of m 6 A‐modified hyaluronan synthase 2 (HAS2) mRNA. HAS2 mRNA and KIAA1429/VIRMA mRNA levels correlate positively in breast cancer tissues, suggesting that the KIAA1429/VIRMA–IGF2BP3–HAS2 axis promotes breast cancer growth and contributes to poor prognosis.","journal":"EMBO Reports","year":2023,"id":326284,"datarank":0.8893887497867329,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.37920914253740945,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.37920914253740945,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":26,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE185494"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":860813,"name":"Zhouting Zhu","orcid":"0000-0001-7763-486X","position":1,"is_corresponding":false},{"id":1045215,"name":"Yufei Deng","orcid":"0009-0000-8776-0747","position":2,"is_corresponding":false},{"id":110447,"name":"R. Tang","orcid":"0000-0003-0364-6280","position":3,"is_corresponding":false},{"id":110448,"name":"Hui Hui","orcid":"0000-0002-6732-4232","position":4,"is_corresponding":false},{"id":110444,"name":"Yuqi Kang","orcid":"0000-0003-0246-248X","position":5,"is_corresponding":false},{"id":69473,"name":"Tariq M. Rana","orcid":"0000-0001-9558-5766","position":6,"is_corresponding":false},{"id":110443,"name":"Na Li","orcid":"0000-0002-2852-8099","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"37705505","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}