{"doi":"10.1523/jneurosci.4745.04.2005","title":"Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4","abstract":"<jats:p>Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4<jats:sup>-/-</jats:sup>mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation<jats:italic>in vivo</jats:italic>. On a thermal gradient, TRPV4<jats:sup>-/-</jats:sup>mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34°C, TRPV4<jats:sup>-/-</jats:sup>mice exhibited a strong preference for 34°C. TRPV4<jats:sup>-/-</jats:sup>mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4<jats:sup>-/-</jats:sup>and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness<jats:italic>in vivo</jats:italic>.</jats:p>","journal":"The Journal of Neuroscience","year":2005,"id":648255,"datarank":10.08833201784191,"base_score":5.662960480135946,"endowment":5.662960480135946,"self_citation_contribution":0.8494440720203921,"citation_network_contribution":9.238887945821519,"self_endowment_contribution":0.8494440720203921,"citer_contribution":9.238887945821519,"corpus_percentile":null,"corpus_rank":null,"citation_count":287,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":209301,"name":"Tohko Iida","orcid":null,"position":1,"is_corresponding":false},{"id":1689265,"name":"Atsuko Mizuno","orcid":null,"position":2,"is_corresponding":false},{"id":1326947,"name":"Makoto Suzuki","orcid":"0000-0002-5494-6593","position":3,"is_corresponding":false},{"id":18764,"name":"Michael J. Caterina","orcid":"0000-0002-7845-5297","position":4,"is_corresponding":false},{"id":154908,"name":"Hyosang Lee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4","abstract":"<jats:p>Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4<jats:sup>-/-</jats:sup>mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation<jats:italic>in vivo</jats:italic>. On a thermal gradient, TRPV4<jats:sup>-/-</jats:sup>mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34°C, TRPV4<jats:sup>-/-</jats:sup>mice exhibited a strong preference for 34°C. TRPV4<jats:sup>-/-</jats:sup>mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4<jats:sup>-/-</jats:sup>and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness<jats:italic>in vivo</jats:italic>.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":null,"pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","oa_locations":[{"url":"https://www.jneurosci.org/content/jneuro/25/5/1304.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.4745.04.2005","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":[],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:25:01.746012Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}