{"doi":"10.1523/jneurosci.3833-10.2011","title":"Functional Connectome of the Striatal Medium Spiny Neuron","abstract":"<jats:p>Dopamine system disorders ranging from movement disorders to addiction and schizophrenia involve striatal medium spiny neurons (MSNs), yet their functional connectivity has been difficult to determine comprehensively. We generated a mouse with conditional channelrhodopsin-2 expression restricted to medium spiny neurons and assessed the specificity and strength of their intrinsic connections in the striatum and their projections to the globus pallidus and the substantia nigra. In the striatum, medium spiny neurons connected with other MSNs and tonically active cholinergic interneurons, but not with fast-spiking GABA interneurons. In the globus pallidus, medium spiny neurons connected strongly with one class of electrophysiologically identified neurons, but weakly with the other. In the substantia nigra, medium spiny neurons connected strongly with GABA, but not with dopamine neurons. Projections to the globus pallidus showed solely D2-mediated presynaptic inhibition, whereas projections to the substantia nigra showed solely D1-mediated presynaptic facilitation. This optogenetic approach defines the functional connectome of the striatal medium spiny neuron.</jats:p>","journal":"The Journal of Neuroscience","year":2011,"id":640686,"datarank":0.8419692159582107,"base_score":5.6131281063880705,"endowment":5.6131281063880705,"self_citation_contribution":0.8419692159582107,"citation_network_contribution":0.0,"self_endowment_contribution":0.8419692159582107,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":273,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1127331,"name":"Kenji F. 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We generated a mouse with conditional channelrhodopsin-2 expression restricted to medium spiny neurons and assessed the specificity and strength of their intrinsic connections in the striatum and their projections to the globus pallidus and the substantia nigra. In the striatum, medium spiny neurons connected with other MSNs and tonically active cholinergic interneurons, but not with fast-spiking GABA interneurons. In the globus pallidus, medium spiny neurons connected strongly with one class of electrophysiologically identified neurons, but weakly with the other. In the substantia nigra, medium spiny neurons connected strongly with GABA, but not with dopamine neurons. Projections to the globus pallidus showed solely D2-mediated presynaptic inhibition, whereas projections to the substantia nigra showed solely D1-mediated presynaptic facilitation. This optogenetic approach defines the functional connectome of the striatal medium spiny neuron.</jats:p>","is_dataset_classified":null,"base_score":5.6131281063880705,"endowment":5.6131281063880705,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21273403","pmcid":"PMC3074638","openalex_id":"https://openalex.org/W1969392675","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R37 MH068542","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH068542","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA017978","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH068542","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA017978","title":null}],"total_grants":5,"fwci":10.579,"citation_percentile":0.99423663,"influential_citations":0,"citation_trend":[{"year":2012,"count":26},{"year":2013,"count":25},{"year":2014,"count":25},{"year":2015,"count":28},{"year":2016,"count":21},{"year":2017,"count":18},{"year":2018,"count":16},{"year":2019,"count":9},{"year":2020,"count":18},{"year":2021,"count":12},{"year":2022,"count":12},{"year":2023,"count":12},{"year":2024,"count":10},{"year":2025,"count":13},{"year":2026,"count":7}],"oa_status":"bronze","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","oa_locations":[{"url":"https://www.jneurosci.org/content/jneuro/31/4/1183.full.pdf","host_type":"journal"},{"url":"https://www.jneurosci.org/content/jneuro/31/4/1183.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.3833-10.2011","host_type":"publisher"},{"url":"https://doi.org/10.1523/jneurosci.3833-10.2011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21273403","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3074638","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Photoreceptor and optogenetics research","Neural dynamics and brain function"],"mesh_terms":["Channelrhodopsins","Action Potentials","Animals","Corpus Striatum","Dopamine","gamma-Aminobutyric Acid","Globus Pallidus","Interneurons","Mice, Transgenic","Neural Inhibition","Neurons","Substantia Nigra","Patch-Clamp Techniques","Dendritic Spines","Mice","Inhibitory Postsynaptic Potentials","In Vitro Techniques"],"keywords":["Medium spiny neuron","Neuroscience","Globus pallidus","Substantia nigra","Striatum","Dopamine","Indirect pathway of movement","Optogenetics","Neuron","Biology","Basal ganglia","Dopaminergic","Central nervous system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T13:15:55.628379Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}