{"doi":"10.1523/jneurosci.0704-06.2006","title":"RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors","abstract":"Secreted Semaphorin3A (Sema3A) proteins are known to act as diffusible and repellant axonal guidance cues during nervous system development. A receptor complex consisting of a Neuropilin and a Plexin-A mediates their effects. Plexin-A signal transduction has remained poorly defined despite the documented involvement of collapsin response mediator protein and molecule interacting with CasL proteins (MICALs) as mediators of Plexin-A activation. Here, we defined a domain of Plexin-A1 required for Sema3A signaling in a reconstituted environment and then searched for proteins interacting with this domain. RanBPM is shown to physically interact with Plexin-A1, and the RanBPM/Plexin complex is regulated by MICAL expression. Overexpression of RanBPM cooperates with PlexinA1 to reduce non-neuronal cell spreading and strongly inhibit axonal outgrowthin vitroandin vivo. A truncated RanBPM protein blocks Sema3A responsiveness in non-neuronal and neuronal cells. Suppression of RanBPM expression reduces Sema3A responsiveness. Thus, RanBPM is a mediator of Sema3A signaling through Plexin-A. RanBPM has the potential to link Plexin-A receptors to retrograde transport and microtubule function in axonal guidance.","journal":"The Journal of Neuroscience","year":2006,"id":35999,"datarank":4.172482170917763,"base_score":4.31748811353631,"endowment":4.31748811353631,"self_citation_contribution":0.6476232170304466,"citation_network_contribution":3.5248589538873167,"self_endowment_contribution":0.6476232170304466,"citer_contribution":3.5248589538873167,"corpus_percentile":null,"corpus_rank":null,"citation_count":74,"citer_count":73,"citers_with_citation_signal":70,"citers_with_endowment":70,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":183196,"name":"Eric F. Schmidt","orcid":null,"position":1,"is_corresponding":false},{"id":182249,"name":"Stephen M. Strittmatter","orcid":null,"position":2,"is_corresponding":false},{"id":183195,"name":"Hideaki Togashi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.31748811353631,"endowment":4.31748811353631,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16672672","pmcid":"PMC2846289","openalex_id":"https://openalex.org/W1987651098","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R37 NS033020","title":null}],"total_grants":1,"fwci":3.8525,"citation_percentile":0.94386379,"influential_citations":8,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":4},{"year":2014,"count":8},{"year":2015,"count":4},{"year":2017,"count":7},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":2}],"oa_status":"bronze","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","oa_locations":[{"url":"https://www.jneurosci.org/content/jneuro/26/18/4961.full.pdf","host_type":"journal"},{"url":"https://www.jneurosci.org/content/jneuro/26/18/4961.full.pdf","host_type":"HYBRID"},{"url":"https://www.jneurosci.org/content/jneuro/26/18/4961.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.0704-06.2006","host_type":"publisher"},{"url":"https://doi.org/10.1523/jneurosci.0704-06.2006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16672672","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2846289","host_type":"repository"}],"fields_of_study":["Axon Guidance and Neuronal Signaling","Zebrafish Biomedical Research Applications","Biology","Medicine","Adaptor Proteins, Signal Transducing","Animals","Cell Adhesion Molecules","Cell Death","Cell Size","Cells, Cultured","Chick Embryo","Cloning, Molecular","Cricetinae","Cricetulus","Cytoskeletal Proteins","Dose-Response Relationship, Drug","Drug Interactions","Enzyme Inhibitors","Ganglia, Spinal","Gene Expression","Green Fluorescent Proteins","Humans","Immunoprecipitation","In Situ Nick-End Labeling","Nerve Tissue Proteins","Neurites","Neurons","Neuropilin-1","Nuclear Proteins","Semaphorin-3A","Signal Transduction","Transcription Factor AP-1","Transfection","Two-Hybrid System Techniques","ran GTP-Binding Protein"],"mesh_terms":["Animals","Cells, Cultured","Chick Embryo","Cloning, Molecular","Cricetulus","Cytoskeletal Proteins","Dose-Response Relationship, Drug","Drug Interactions","Enzyme Inhibitors","Ganglia, Spinal","Cricetinae","Humans","Nerve Tissue Proteins","Neurons","Nuclear Proteins","Transfection","Signal Transduction","Cell Adhesion Molecules","Gene Expression","Neurites","Cell Death","Transcription Factor AP-1","In Situ Nick-End Labeling","Two-Hybrid System Techniques","ran GTP-Binding Protein","Neuropilin-1","Semaphorin-3A","Immunoprecipitation","Cell Size","Adaptor Proteins, Signal Transducing","Green Fluorescent Proteins"],"keywords":["Plexin","Semaphorin","SEMA3A","Neuropilin 1","Cell biology","Mediator","Signal transduction","Receptor","Neuroscience","Biology","Neuropilin","Cancer research","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T13:05:20.756317Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}