{"doi":"10.1523/jneurosci.0613-20.2020","title":"Paracrine Role for Somatostatin Interneurons in the Assembly of Perisomatic Inhibitory Synapses","abstract":"GABAergic interneurons represent a heterogenous group of cell types in neocortex that can be clustered based on developmental origin, morphology, physiology, and connectivity. Two abundant populations of cortical GABAergic interneurons include the low-threshold, somatostatin (SST)-expressing cells and the fast-spiking, parvalbumin (PV)-expressing cells. While SST 1 and PV 1 interneurons are both early born and migrate into the developing neocortex at similar times, SST 1 cells are incorporated into functional circuits prior to PV 1 cells. During this early period of neural development, SST 1 cells play critical roles in the assembly and maturation of other cortical circuits; however, the mechanisms underlying this process remain poorly understood. Here, using both sexes of conditional mutant mice, we discovered that SST 1 interneuron-derived Collagen XIX, a synaptogenic extracellular matrix protein, is required for the formation of GABAergic, perisomatic synapses by PV 1 cells. These results, therefore, identify a paracrine mechanism by which early-born SST 1 cells orchestrate inhibitory circuit formation in the developing neocortex.","journal":"Journal of Neuroscience","year":2020,"id":103372,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9459,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":504120,"name":"Danielle Basso","orcid":null,"position":1,"is_corresponding":false},{"id":504121,"name":"Shivani Iyer","orcid":null,"position":2,"is_corresponding":false},{"id":504122,"name":"Kaiwen Su","orcid":null,"position":3,"is_corresponding":false},{"id":438162,"name":"Jessica Wei","orcid":"0000-0002-7329-2812","position":4,"is_corresponding":false},{"id":348073,"name":"Michael A. Fox","orcid":"0000-0002-1649-7782","position":5,"is_corresponding":false},{"id":411212,"name":"Jianmin Su","orcid":"0000-0001-7353-1265","position":0,"is_corresponding":true}],"reference_count":131,"raw_metadata":null,"created_at":"2026-07-18T22:42:17.920911Z","pmid":"32847968","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}