{"doi":"10.1523/jneurosci.0374-05.2005","title":"Stimulus-Dependent γ (30-50 Hz) Oscillations in Simple and Complex Fast Rhythmic Bursting Cells in Primary Visual Cortex","abstract":"<jats:p>\n                    Oscillatory activity is generated by many neural systems. γ band (∼40 Hz) oscillations in the thalamus and cortex occur spontaneously and in response to sensory stimuli. Fast rhythmic bursting (FRB) cells (also called chattering cells) comprise a unique class of cortical neurons that, during depolarization by current injection, intrinsically generate bursts of high-frequency action potentials with an interburst frequency between 30 and 50 Hz. In the present study, we show for the first time that FRB cells in the primary visual cortex can be either simple or complex and are distributed throughout all cortical layers. Strikingly, both simple and complex FRB cells generate spike bursts at γ frequencies in response to depolarizing current pulses, but only simple FRB cells exhibit a selective, stimulus feature-dependent increase in γ oscillations in response to visual stimulation. In addition, we find that hyperpolarization does not reduce the relative power of visually evoked γ oscillations in the\n                    <jats:italic>V</jats:italic>\n                    <jats:sub>m</jats:sub>\n                    response of FRB cells. Our results thus indicate that visually evoked γ activity in individual simple and complex FRB cells is generated in large part by rhythmic synaptic input, rather than by depolarization-dependent activation of intrinsic properties. Finally, the presence of FRB cells in layer 6 suggests a role for corticothalamic feedback in potentiating thalamic oscillations and facilitating the generation of a corticothalamocortical oscillatory loop. We propose that rather than functioning as pacemakers, FRB cells amplify and distribute stimulus-driven γ oscillations in the neocortex.\n                  </jats:p>","journal":"The Journal of Neuroscience","year":2005,"id":684013,"datarank":0.6698862177981877,"base_score":4.465908118654584,"endowment":4.465908118654584,"self_citation_contribution":0.6698862177981877,"citation_network_contribution":0.0,"self_endowment_contribution":0.6698862177981877,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1733364,"name":"Larry A. Palmer","orcid":null,"position":1,"is_corresponding":false},{"id":775289,"name":"Diego Contreras","orcid":"0000-0003-0197-9882","position":2,"is_corresponding":false},{"id":553478,"name":"Jessica A. Cardin","orcid":"0000-0002-8209-5466","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Stimulus-Dependent γ (30-50 Hz) Oscillations in Simple and Complex Fast Rhythmic Bursting Cells in Primary Visual Cortex","abstract":"<jats:p>\n                    Oscillatory activity is generated by many neural systems. γ band (∼40 Hz) oscillations in the thalamus and cortex occur spontaneously and in response to sensory stimuli. Fast rhythmic bursting (FRB) cells (also called chattering cells) comprise a unique class of cortical neurons that, during depolarization by current injection, intrinsically generate bursts of high-frequency action potentials with an interburst frequency between 30 and 50 Hz. In the present study, we show for the first time that FRB cells in the primary visual cortex can be either simple or complex and are distributed throughout all cortical layers. Strikingly, both simple and complex FRB cells generate spike bursts at γ frequencies in response to depolarizing current pulses, but only simple FRB cells exhibit a selective, stimulus feature-dependent increase in γ oscillations in response to visual stimulation. In addition, we find that hyperpolarization does not reduce the relative power of visually evoked γ oscillations in the\n                    <jats:italic>V</jats:italic>\n                    <jats:sub>m</jats:sub>\n                    response of FRB cells. Our results thus indicate that visually evoked γ activity in individual simple and complex FRB cells is generated in large part by rhythmic synaptic input, rather than by depolarization-dependent activation of intrinsic properties. Finally, the presence of FRB cells in layer 6 suggests a role for corticothalamic feedback in potentiating thalamic oscillations and facilitating the generation of a corticothalamocortical oscillatory loop. We propose that rather than functioning as pacemakers, FRB cells amplify and distribute stimulus-driven γ oscillations in the neocortex.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.465908118654584,"endowment":4.465908118654584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15930382","pmcid":"PMC3034157","openalex_id":"https://openalex.org/W1968111083","authors":[],"funders":[{"funder_name":"NEI NIH HHS","grant_id":"R01 EY016430","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"P50 MH064045","title":null}],"total_grants":2,"fwci":2.4837,"citation_percentile":0.8839866,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","oa_locations":[{"url":"https://www.jneurosci.org/content/jneuro/25/22/5339.full.pdf","host_type":"journal"},{"url":"https://www.jneurosci.org/content/jneuro/25/22/5339.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.0374-05.2005","host_type":"publisher"},{"url":"https://doi.org/10.1523/jneurosci.0374-05.2005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15930382","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3034157","host_type":"repository"}],"fields_of_study":["Neural dynamics and brain function","Photoreceptor and optogenetics research","Neuroscience and Neuropharmacology Research","Action Potentials","Animals","Cats","Evoked Potentials, Visual","Periodicity","Photic Stimulation","Visual Cortex"],"mesh_terms":["Action Potentials","Animals","Cats","Evoked Potentials, Visual","Periodicity","Photic Stimulation","Visual Cortex"],"keywords":["Bursting","Depolarization","Neuroscience","Stimulus (psychology)","Neocortex","Visual cortex","Inhibitory postsynaptic potential","Thalamus","Rhythm","Physics","Stimulation","Sensory system","Biology","Biophysics","Psychology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T13:03:48.884058Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}