{"doi":"10.1523/hon.012007","title":"Gail Mandel","abstract":"She was among the first to clone and functionally express ion channels with a principal focus on the voltage-dependent sodium channel.Her research led to identification of the genetic elements that control neuronal-specific expression and, ultimately, mechanisms that underlie the development of the nervous system.Contrary to expectations, her identification of the transcription factor, REST, showed that the acquisition of a terminally differentiated neuronal phenotype was not due to activators but rather to lack of this repressor.REST has been shown subsequently to be a master regulator for a wide cast of genes, many of which underlie human neuropathologies, including diseases external to the nervous system.She recently applied her background on gene repression to study of the transcriptional repressor, MeCP2, and its role in human diseases, showing that RETT is a disease involving both neuronal and glial dysfunction, thereby developing therapeutic approaches toward a cure.","journal":"Society for Neuroscience eBooks","year":2022,"id":314259,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T00:33:52.047924Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}