{"doi":"10.1517/14622416.6.2.115","title":"Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2","abstract":null,"journal":"Pharmacogenomics","year":2005,"id":612792,"datarank":0.7230422348407557,"base_score":4.820281565605037,"endowment":4.820281565605037,"self_citation_contribution":0.7230422348407557,"citation_network_contribution":0.0,"self_endowment_contribution":0.7230422348407557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":123,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1577986,"name":"Kees Nooter","orcid":null,"position":1,"is_corresponding":false},{"id":1577987,"name":"Jaap Verweij","orcid":null,"position":2,"is_corresponding":false},{"id":1577988,"name":"Milin R Acharya","orcid":null,"position":3,"is_corresponding":false},{"id":1445187,"name":"William D Figg","orcid":null,"position":4,"is_corresponding":false},{"id":255308,"name":"Alex Sparreboom","orcid":"0000-0003-2660-6644","position":5,"is_corresponding":false},{"id":1577985,"name":"Erin R Lepper","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2","abstract":"ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein) and ABCG2 (breast cancer-resistance protein [BCRP], mitoxantrone-resistance protein [MXR], or ABC transporter in placenta [ABCP]), are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenetics of the ABC transporters ABCB1 and ABCG2, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer.","is_dataset_classified":null,"base_score":4.820281565605037,"endowment":4.820281565605037,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15882131","pmcid":null,"openalex_id":"https://openalex.org/W2029638992","authors":[],"funders":[],"total_grants":0,"fwci":5.3757,"citation_percentile":0.96597483,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":2},{"year":2014,"count":12},{"year":2015,"count":6},{"year":2016,"count":3},{"year":2018,"count":4},{"year":2019,"count":6},{"year":2020,"count":3},{"year":2021,"count":6},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1517/14622416.6.2.115","host_type":"publisher"},{"url":"https://doi.org/10.1517/14622416.6.2.115","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15882131","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/4547f1b3-1906-448f-be2d-337d23a0b99b","host_type":"repository"},{"url":"http://hdl.handle.net/1765/71178","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","HIV/AIDS drug development and treatment","Pharmacological Effects and Toxicity Studies","ATP Binding Cassette Transporter, Subfamily B","ATP Binding Cassette Transporter, Subfamily B, Member 1","ATP Binding Cassette Transporter, Subfamily G, Member 2","ATP-Binding Cassette Transporters","Antineoplastic Agents","Area Under Curve","Biological Transport","Drug Resistance, Neoplasm","Humans","Neoplasm Proteins","Organic Anion Transporters","Polymorphism, Genetic"],"mesh_terms":["ATP Binding Cassette Transporter, Subfamily G, Member 2","Antineoplastic Agents","Biological Transport","Humans","Neoplasm Proteins","Polymorphism, Genetic","ATP Binding Cassette Transporter, Subfamily B","ATP-Binding Cassette Transporters","Drug Resistance, Neoplasm","Area Under Curve","ATP Binding Cassette Transporter, Subfamily B, Member 1","Organic Anion Transporters"],"keywords":["Abcg2","ATP-binding cassette transporter","Mitoxantrone","Transporter","Efflux","Pharmacology","Pharmacogenetics","P-glycoprotein","Biology","Multidrug Resistance-Associated Proteins","Multiple drug resistance","Gene","Drug resistance","Drug","Genetics","Genotype","Chemotherapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T04:59:03.355923Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}