{"doi":"10.1517/13543784.14.12.1497","title":"Histone deacetylase inhibitors: discovery and development as anticancer agents","abstract":null,"journal":"Expert Opinion on Investigational Drugs","year":2005,"id":416021,"datarank":13.16597530479472,"base_score":5.762051382780177,"endowment":5.762051382780177,"self_citation_contribution":0.8643077074170267,"citation_network_contribution":12.301667597377694,"self_endowment_contribution":0.8643077074170267,"citer_contribution":12.301667597377694,"corpus_percentile":null,"corpus_rank":null,"citation_count":317,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1198514,"name":"Milos Dokmanovic","orcid":null,"position":1,"is_corresponding":false},{"id":1198513,"name":"Paul A Marks","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Histone deacetylase inhibitors: discovery and development as anticancer agents","abstract":"Histone deacetylase (HDAC) inhibitors are a new class of targeted anticancer agents. Several HDAC inhibitors are in clinical trials and have shown significant activity against a spectrum of both haematological and solid tumours at doses that are well tolerated by patients. HDACs and histone acetyltransferases can, by reversible acetylation, modify the structure and function of histones and proteins in transcription factor complexes, which are involved in the regulation of gene expression, as well as many non-histone proteins that are involved in regulating cell proliferation and cell death. HDAC inhibitors are a structurally diverse group of molecules; these agents selectively alter the expression of genes. HDAC inhibitors can induce cancer cell death, whereas normal cells are relatively resistant to HDAC inhibitor-induced cell death.","is_dataset_classified":null,"base_score":5.762051382780177,"endowment":5.762051382780177,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16307490","pmcid":null,"openalex_id":"https://openalex.org/W2162438863","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA-0974823","title":null}],"total_grants":1,"fwci":8.064,"citation_percentile":0.98477489,"influential_citations":0,"citation_trend":[{"year":2012,"count":21},{"year":2013,"count":19},{"year":2014,"count":18},{"year":2015,"count":20},{"year":2016,"count":12},{"year":2017,"count":12},{"year":2018,"count":12},{"year":2019,"count":16},{"year":2020,"count":15},{"year":2021,"count":9},{"year":2022,"count":6},{"year":2023,"count":9},{"year":2024,"count":3},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.tandfonline.com/doi/pdf/10.1517/13543784.14.12.1497","host_type":"publisher"},{"url":"https://doi.org/10.1517/13543784.14.12.1497","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16307490","host_type":"repository"}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Protein Degradation and Inhibitors","Nuclear Receptors and Signaling","Animals","Antineoplastic Agents","Drug Delivery Systems","Drug Design","Enzyme Inhibitors","Histone Deacetylase Inhibitors","Humans"],"mesh_terms":["Animals","Antineoplastic Agents","Enzyme Inhibitors","Humans","Drug Design","Drug Delivery Systems","Histone Deacetylase Inhibitors"],"keywords":["Histone deacetylase","Histone deacetylase 5","HDAC11","Acetylation","Histone Acetyltransferases","Histone","Histone deacetylase 2","Cancer research","Biology","Programmed cell death","HDAC10","Transcription factor","Cell biology","Chemistry","Biochemistry","Gene","Apoptosis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-19T01:36:36.463397Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}