{"doi":"10.1517/13543784.13.9.1135","title":"The farnesoid X receptor: a novel drug target?","abstract":null,"journal":"Expert Opinion on Investigational Drugs","year":2004,"id":626050,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":641858,"name":"Ekkehard Sturm","orcid":"0000-0002-1489-8662","position":1,"is_corresponding":false},{"id":603383,"name":"Folkert Kuipers","orcid":"0000-0003-2518-737X","position":2,"is_corresponding":false},{"id":332364,"name":"Bart Staels","orcid":"0000-0002-3784-1503","position":3,"is_corresponding":false},{"id":1619331,"name":"Thierry Claudel","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The farnesoid X receptor: a novel drug target?","abstract":"Bile acids are end products of cholesterol metabolism. They are exclusively synthesised by the liver and subsequently secreted via the bile duct into the intestine to facilitate the absorption of dietary fat and fat-soluble vitamins. Nuclear receptors are ligand-activated transcription factors. The farnesoid X receptor (FXR) has recently been identified as a bile acid-activated nuclear receptor. FXR controls bile-acid synthesis, conjugation and transport, as well as lipid metabolism. Recent advances in FXR biology demonstrate that FXR may represent a valuable target for the identification of novel drugs to treat dyslipidaemia and cholestasis. However, for therapeutic purposes the development of selective FXR modulators, which only activate or inhibit specific FXR target genes and as such induce specific responses, will be required.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15330745","pmcid":null,"openalex_id":"https://openalex.org/W2129871925","authors":[],"funders":[],"total_grants":0,"fwci":2.7796,"citation_percentile":0.9078174,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":3},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2021,"count":1},{"year":2023,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1517/13543784.13.9.1135","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15330745","host_type":"repository"},{"url":"https://research.rug.nl/en/publications/c72c9197-77dd-4f69-8f71-5a71bb1f0576","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Cholesterol and Lipid Metabolism","Trace Elements in Health","Animals","Benzene Derivatives","Caprylates","Chenodeoxycholic Acid","Cholestasis","DNA-Binding Proteins","Humans","Hyperlipidemias","Hypolipidemic Agents","Molecular Structure","Phenyl Ethers","Receptors, Cytoplasmic and Nuclear","Transcription Factors","Receptor, Farnesoid X-Activated"],"mesh_terms":["Receptor, Farnesoid X-Activated","Animals","Hypolipidemic Agents","Benzene Derivatives","Caprylates","Chenodeoxycholic Acid","Cholestasis","DNA-Binding Proteins","Humans","Hyperlipidemias","Phenyl Ethers","Transcription Factors","Molecular Structure","Receptors, Cytoplasmic and Nuclear"],"keywords":["Farnesoid X receptor","Nuclear receptor","Bile acid","Cholestasis","Small heterodimer partner","Receptor","Biochemistry","Lipid metabolism","Drug metabolism","Transcription factor","Chemistry","Biology","Metabolism","Internal medicine","Pharmacology","Endocrinology","Gene","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T12:09:19.190439Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}