{"doi":"10.1515/med-2023-0802","title":"Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Can the spinal cord stimulation (SCS) regulate the autonomic nerves through the endothelin-1 (ET-1) and nerve growth factor (NGF)/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation (AF)? In our research, 16 beagles were randomly divided into a rapid atrial pacing (RAP) group (<jats:italic>n</jats:italic> = 8) and a RAP + SCS group (<jats:italic>n</jats:italic> = 8), and the effective refractory period (ERP), ERP dispersion, AF induction rate, and AF vulnerability window (WOV) at baseline, 6 h of RAP, 6 h of RAP + SCS were measured. The atrial tissue was then taken for immunohistochemical analysis to determine the localization of ET-1, NGF, p75NTR, NF-kB p65, and other genes. Our results showed that SCS attenuated the shortening of ERP in all parts caused by RAP, and after 6 h of SCS, the probability of AF in dogs was reduced compared with that in the RAP group. Moreover, the expression of ET-1, NGF, and p75NTR in the atrial tissues of dogs in the RAP + SCS group was significantly increased, but the expression of NF-kB p65 was reduced. In conclusion, SCS promotes the positive remodeling of cardiac autonomic nerves by weakening NFκB p65-dependent pathways to interfere with the ET-1 and NGF/p75NTR pathways to resist the original negative remodeling and inhibit the occurrence of AF.</jats:p>","journal":"Open Medicine","year":2023,"id":633940,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":399792,"name":"Peng Li","orcid":"0000-0002-3362-0543","position":1,"is_corresponding":false},{"id":406507,"name":"Wei Hu","orcid":"0000-0002-4138-7905","position":2,"is_corresponding":false},{"id":515224,"name":"Qi Shao","orcid":"0000-0002-8190-1067","position":3,"is_corresponding":false},{"id":1563064,"name":"Panpan Li","orcid":null,"position":4,"is_corresponding":false},{"id":1643855,"name":"Haiyue Wen","orcid":null,"position":5,"is_corresponding":false},{"id":1643853,"name":"Yiyan Peng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Can the spinal cord stimulation (SCS) regulate the autonomic nerves through the endothelin-1 (ET-1) and nerve growth factor (NGF)/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation (AF)? In our research, 16 beagles were randomly divided into a rapid atrial pacing (RAP) group (<jats:italic>n</jats:italic> = 8) and a RAP + SCS group (<jats:italic>n</jats:italic> = 8), and the effective refractory period (ERP), ERP dispersion, AF induction rate, and AF vulnerability window (WOV) at baseline, 6 h of RAP, 6 h of RAP + SCS were measured. The atrial tissue was then taken for immunohistochemical analysis to determine the localization of ET-1, NGF, p75NTR, NF-kB p65, and other genes. Our results showed that SCS attenuated the shortening of ERP in all parts caused by RAP, and after 6 h of SCS, the probability of AF in dogs was reduced compared with that in the RAP group. Moreover, the expression of ET-1, NGF, and p75NTR in the atrial tissues of dogs in the RAP + SCS group was significantly increased, but the expression of NF-kB p65 was reduced. In conclusion, SCS promotes the positive remodeling of cardiac autonomic nerves by weakening NFκB p65-dependent pathways to interfere with the ET-1 and NGF/p75NTR pathways to resist the original negative remodeling and inhibit the occurrence of AF.</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37808162","pmcid":"PMC10560034","openalex_id":"https://openalex.org/W4387385213","authors":[],"funders":[],"total_grants":0,"fwci":0.2911,"citation_percentile":0.59168131,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.degruyter.com/document/doi/10.1515/med-2023-0802/pdf","host_type":"journal"},{"url":"https://www.degruyter.com/document/doi/10.1515/med-2023-0802/pdf","host_type":"publisher"},{"url":"https://www.degruyter.com/document/doi/10.1515/med-2023-0802/xml","host_type":"publisher"},{"url":"https://doi.org/10.1515/med-2023-0802","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37808162","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560034","host_type":"repository"},{"url":"https://doaj.org/article/0aa9f914d00a40ebb0a90fcad6fd1e55","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560034/pdf/med-2023-0802.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10560034","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10560034?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Pain Management and Treatment","Atrial Fibrillation Management and Outcomes","Nitric Oxide and Endothelin Effects"],"mesh_terms":[],"keywords":["Medicine","Nerve growth factor","Atrial fibrillation","Stimulation","Internal medicine","Immunohistochemistry","Endothelin receptor","Endocrinology","Spinal cord","Cardiology","Anesthesia","Receptor","Endothelin-1","P75NTR","Spinal Cord Stimulation","Autonomic Nerves","Nf-kb P65"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T12:54:11.683352Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}