{"doi":"10.1515/cclm-2011-0234","title":"Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity during surgery-induced inflammation in humans","abstract":null,"journal":"Clinical Chemistry and Laboratory Medicine","year":2012,"id":649821,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1694149,"name":"Torbjörn Åkerfeldt","orcid":null,"position":1,"is_corresponding":false},{"id":1694151,"name":"Lena Gunningberg","orcid":null,"position":2,"is_corresponding":false},{"id":1694152,"name":"Christine Leo Swenne","orcid":null,"position":3,"is_corresponding":false},{"id":908961,"name":"Anders Larsson","orcid":"0000-0003-3161-0402","position":4,"is_corresponding":false},{"id":1694147,"name":"Johanna Helmersson-Karlqvist","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity during surgery-induced inflammation in humans","abstract":"BACKGROUND: Matrix metalloproteinase 9 (MMP-9) and the endogenous inhibitor to MMP-9, tissue inhibitor of metalloproteinase 1 (TIMP-1), have important roles in tissue remodelling and are implicated in a number of diseases related to inflammation. The time course in activation and formation of MMPs and TIMPs during an inflammatory reaction is not fully known. This study investigates MMP-9 and TIMP-1 concentrations and MMP-9 activity at different time points after major surgery when a state of noticeable inflammation is expected. METHODS: Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity were analysed preoperatively and 4 and 30 days postoperatively in patients undergoing elective surgery (coronary artery bypass n=21; orthopaedic surgery, n=29). RESULTS: Serum TIMP-1 and MMP-9 activity increased significantly 4 days after surgery (p<0.05 and p<0.01, respectively) and decreased again 30 days after surgery (p<0.01, respectively, compared to 4 days after surgery). Serum MMP-9 increased significantly 4 days after surgery (p<0.05) and was still high 30 days after surgery (p<0.01 compared to before surgery). The calculated MMP-9/TIMP-1 ratio was increased 30 days after surgery compared to before surgery (p<0.01). CONCLUSIONS: The inflammatory state induced by elective surgery is associated with increased TIMP-1 response and MMP-9 activity in serum within a few days which may be of importance for the postoperative heeling process. The further increase in MMP-9 concentrations at day 30 postoperative did not result in increased MMP-9 activity. Serum MMP-9 concentrations or the calculated MMP-9/TIMP-1 ratio do not entirely represent MMP-9 activity during surgery-induced inflammation.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22706255","pmcid":null,"openalex_id":"https://openalex.org/W2049658025","authors":[],"funders":[],"total_grants":0,"fwci":0.5209,"citation_percentile":0.70207996,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2020,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.degruyter.com/document/doi/10.1515/cclm-2011-0234/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1515/cclm-2011-0234","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22706255","host_type":"repository"}],"fields_of_study":["Cardiac, Anesthesia and Surgical Outcomes","Protease and Inhibitor Mechanisms","Cancer, Stress, Anesthesia, and Immune Response"],"mesh_terms":["Aged","Aged, 80 and over","Coronary Artery Bypass","Female","Humans","Inflammation","Male","Middle Aged","Orthopedics","Postoperative Complications","Linear Models","Tissue Inhibitor of Metalloproteinase-1","Matrix Metalloproteinase 9"],"keywords":["Matrix metalloproteinase","Inflammation","Tissue inhibitor of metalloproteinase","Metalloproteinase","Endogeny","Matrix Metalloproteinase 3","Medicine","Pathology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:22:00.002358Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}