{"doi":"10.1515/bmc-2021-0015","title":"Characterization of Differentially Expressed miRNAs by CXCL12/SDF-1 in Human Bone Marrow Stromal Cells","abstract":"Stromal cell-derived factor 1 (SDF-1) is known to influence bone marrow stromal cell (BMSC) migration, osteogenic differentiation, and fracture healing. We hypothesize that SDF-1 mediates some of its effects on BMSCs through epigenetic regulation, specifically via microRNAs (miRNAs). MiRNAs are small non-coding RNAs that target specific mRNA and prevent their translation. We performed global miRNA analysis and determined several miRNAs were differentially expressed in response to SDF-1 treatment. Gene Expression Omnibus (GEO) dataset analysis showed that these miRNAs play an important role in osteogenic differentiation and fracture healing. KEGG and GO analysis indicated that SDF-1 dependent miRNAs changes affect multiple cellular pathways, including fatty acid biosynthesis, thyroid hormone signaling, and mucin-type O-glycan biosynthesis pathways. Furthermore, bioinformatics analysis showed several miRNAs target genes related to stem cell migration and differentiation. This study's findings indicated that SDF-1 induces some of its effects on BMSCs function through miRNA regulation.","journal":"BioMolecular Concepts","year":2021,"id":193354,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9603,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":519080,"name":"Kathryn E. Smith","orcid":"0000-0001-6555-0060","position":1,"is_corresponding":false},{"id":705057,"name":"Sagar Vyavahare","orcid":"0000-0003-0047-9368","position":2,"is_corresponding":false},{"id":45533,"name":"Sandeep Kumar","orcid":"0000-0001-7181-232X","position":3,"is_corresponding":false},{"id":394095,"name":"Sudharsan Periyasamy‐Thandavan","orcid":null,"position":4,"is_corresponding":false},{"id":266798,"name":"Mark W. Hamrick","orcid":"0000-0003-2246-3121","position":5,"is_corresponding":false},{"id":264783,"name":"Carlos M. Isales","orcid":"0000-0002-4480-3484","position":6,"is_corresponding":false},{"id":350532,"name":"William Hill","orcid":"0000-0002-7968-0584","position":7,"is_corresponding":false},{"id":264778,"name":"Sadanand Fulzele","orcid":"0000-0002-3510-6759","position":8,"is_corresponding":false},{"id":351202,"name":"Matthew L. Potter","orcid":"0000-0002-1292-6738","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T23:49:51.300073Z","pmid":"34648701","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}