{"doi":"10.1515/bc.2006.182","title":"Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs","abstract":"<jats:title>Abstract</jats:title>\n            <jats:p>The biogenesis of spliceosomal small nuclear RNAs (snRNAs) involves organized translocations between the cytoplasm and certain nuclear domains, such as Cajal bodies and nucleoli. Here we identify human RBM28 protein as a novel snRNP component, based on affinity selection of U6 small nuclear ribonucleoprotein (snRNP). As shown by immunofluorescence, RBM28 is a nucleolar protein. Anti-RBM28 immunoprecipitation from HeLa cell lysates revealed that this protein specifically associates with U1, U2, U4, U5, and U6 snRNAs. Our data provide the first evidence that RBM28 is a common nucleolar component of the spliceosomal ribonucleoprotein complexes, possibly coordinating their transition through the nucleolus.</jats:p>","journal":"Biological Chemistry","year":2006,"id":34899,"datarank":1.4204004445480944,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.9436923699959024,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.9436923699959024,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":21,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":179893,"name":"Michael Kann","orcid":null,"position":1,"is_corresponding":false},{"id":49846,"name":"William S. Lane","orcid":null,"position":2,"is_corresponding":false},{"id":179894,"name":"Albrecht Bindereif","orcid":null,"position":3,"is_corresponding":false},{"id":179892,"name":"Andrey Damianov","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17081119","pmcid":null,"openalex_id":"https://openalex.org/W1995760492","authors":[],"funders":[],"total_grants":0,"fwci":0.1363,"citation_percentile":0.51061716,"influential_citations":2,"citation_trend":[{"year":2013,"count":1},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.degruyter.com/view/j/bchm.2006.387.issue-10_11/bc.2006.182/bc.2006.182.xml","host_type":"publisher"},{"url":"https://www.degruyter.com/document/doi/10.1515/BC.2006.182/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1515/bc.2006.182","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17081119","host_type":"repository"},{"url":"https://hal.science/hal-00166161","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","RNA modifications and cancer","RNA and protein synthesis mechanisms","Biology","Medicine"],"mesh_terms":["Cell Nucleolus","HeLa Cells","Humans","Nuclear Proteins","Protein Binding","Mass Spectrometry","Spliceosomes","Ribonucleoproteins, Small Nuclear","Hela Cells"],"keywords":["snRNP","Cajal body","Nucleolus","Small nuclear ribonucleoprotein","Ribonucleoprotein","Small nuclear RNA","Cell biology","Immunoprecipitation","Nucleoplasm","Biology","Biogenesis","Nuclear protein","Spliceosome","RNA","Cytoplasm","Chemistry","RNA splicing","Genetics","Gene","Non-coding RNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T21:02:07.169257Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}