{"doi":"10.1507/endocrj1954.38.67","title":"Effects of Estrogen on Growth of Androgen-responsive Rat Prostatic Tumor (R 3327).","abstract":null,"journal":"Endocrinologia Japonica","year":1991,"id":607877,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1560963,"name":"NAOHIDE SATO","orcid":null,"position":1,"is_corresponding":false},{"id":1560964,"name":"YOSHI WATABE","orcid":null,"position":2,"is_corresponding":false},{"id":143756,"name":"JUN SHIMAZAKI","orcid":null,"position":3,"is_corresponding":false},{"id":1560962,"name":"YUZO FURUYA","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of Estrogen on Growth of Androgen-responsive Rat Prostatic Tumor (R 3327).","abstract":"It has been known that estrogen has synergistic effects with androgen on growth of normal male accessory sex organs of rats. The present study was therefore undertaken to examine the effects of estrogen on androgen-responsive rat Dunning R 3327 prostatic tumor. The weight of male accessory sex organs was suppressed by estrogen on growth of treatment, but synergistic effects of estrogen and androgen on these organs were seen following combined treatment with androgen and estrogen. In contrast to the effects of estrogen on accessory sex organs, estrogen influenced a R 3327 tumor only in the negative direction regardless of whether androgen was injected simultaneously or not. When the dihydrotestosterone injection was reduced from 500 to 100 micrograms/rat/day after the tumor appeared as subcutaneous nodules, the weight of the accessory sex organs was similar to that of the control animals. However, this amount of dihydrotestosterone increased tumor growth equally when compared to those treated with a pharmacological dose of dihydrotestosterone. Therefore, the response of R 3327 tumor to androgen was different from that of the accessory sex organs.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1915114","pmcid":null,"openalex_id":"https://openalex.org/W1998105574","authors":[],"funders":[],"total_grants":0,"fwci":0.5351,"citation_percentile":0.58895574,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/endocrj1954/38/1/38_1_67/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/endocrj1954/38/1/38_1_67/_pdf","host_type":"publisher"},{"url":"http://www.jstage.jst.go.jp/article/endocrj1954/38/1/38_1_67/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1507/endocrj1954.38.67","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1915114","host_type":"repository"}],"fields_of_study":["Meat and Animal Product Quality","Biochemical effects in animals","Hormonal and reproductive studies"],"mesh_terms":["Animals","Castration","Dose-Response Relationship, Drug","Drug Antagonism","Estradiol","Humans","Injections, Subcutaneous","Male","Neoplasm Transplantation","Neoplasms, Hormone-Dependent","Organ Size","Prostate","Prostatic Neoplasms","Rats, Inbred Strains","Seminal Vesicles","Sex Factors","Dihydrotestosterone","Testosterone","Rats"],"keywords":["Estrogen","Androgen","Internal medicine","Endocrinology","Medicine","Gynecology","Hormone"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:09:51.157994Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}