{"doi":"10.1507/endocrj.ej23-0629","title":"Association between DNA methylation levels of <i>thioredoxin-interacting protein (TXNIP)</i> and changes in glycemic traits: a longitudinal population-based study","abstract":null,"journal":"Endocrine Journal","year":2024,"id":613303,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1579938,"name":"Ryosuke Fujii","orcid":"0000-0003-1730-2059","position":1,"is_corresponding":false},{"id":1579940,"name":"Hiroya Yamada","orcid":null,"position":2,"is_corresponding":false},{"id":1579941,"name":"Eiji Munetsuna","orcid":null,"position":3,"is_corresponding":false},{"id":1579942,"name":"Mirai Yamazaki","orcid":null,"position":4,"is_corresponding":false},{"id":1579943,"name":"Yoshitaka Ando","orcid":null,"position":5,"is_corresponding":false},{"id":1579944,"name":"Genki Mizuno","orcid":null,"position":6,"is_corresponding":false},{"id":201075,"name":"Hiroaki Ishikawa","orcid":null,"position":7,"is_corresponding":false},{"id":201076,"name":"Koji Ohashi","orcid":null,"position":8,"is_corresponding":false},{"id":1579947,"name":"Yoshiki Tsuboi","orcid":"0000-0001-8145-3949","position":9,"is_corresponding":false},{"id":1562457,"name":"Yuji Hattori","orcid":null,"position":10,"is_corresponding":false},{"id":1579950,"name":"Yuya Ishihara","orcid":null,"position":11,"is_corresponding":false},{"id":130242,"name":"Nobuyuki Hamajima","orcid":null,"position":12,"is_corresponding":false},{"id":185868,"name":"Shuji Hashimoto","orcid":null,"position":13,"is_corresponding":false},{"id":1175056,"name":"Koji Suzuki","orcid":"0000-0001-5354-1044","position":14,"is_corresponding":false},{"id":1579936,"name":"Keisuke Maeda","orcid":"0000-0001-8916-2687","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association between DNA methylation levels of <i>thioredoxin-interacting protein (TXNIP)</i> and changes in glycemic traits: a longitudinal population-based study","abstract":"Thioredoxin-interacting protein (TXNIP) plays an important role in glucose metabolism, and its expression is regulated by DNA methylation (DNAm). Although the association between TXNIP DNAm and type 2 diabetes mellitus has been demonstrated in studies with a cross-sectional design, prospective studies are needed. We therefore examined the association between TXNIP DNAm levels and longitudinal changes in glycemic traits by conducting a longitudinal study involving 169 subjects who underwent two health checkups in 2015 and 2019. We used a pyrosequencing assay to determine TXNIP DNAm levels in leukocytes (cg19693031). Logistic regression analyses were performed to assess the associations between dichotomized TXNIP DNAm levels and marked increases in glycemic traits. At four years, the TXNIP DNA hypomethylation group had a higher percentage of changes in fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) compared to those in the hypermethylation group. The adjusted odds ratios for FPG and HbA1c levels were significantly higher in the TXNIP DNA hypomethylation group than in the hypermethylation group. We found that TXNIP DNA hypomethylation at baseline was associated with a marked increase in glycemic traits. Leukocyte TXNIP DNAm status could potentially be used as an early biomarker for impaired glucose homeostasis.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38538307","pmcid":null,"openalex_id":"https://openalex.org/W4393216280","authors":[],"funders":[],"total_grants":0,"fwci":0.4853,"citation_percentile":0.59382455,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ23-0629/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ23-0629/_pdf","host_type":"publisher"},{"url":"https://www.jstage.jst.go.jp/article/endocrj/71/6/71_EJ23-0629/_pdf","host_type":"publisher"},{"url":"http://dx.doi.org/10.1507/endocrj.ej23-0629","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38538307","host_type":"repository"},{"url":"https://www.jstage.jst.go.jp/article/endocrj/71/6/71_EJ23-0629/_article","host_type":"journal"},{"url":"https://doaj.org/article/c887e932ac4a41ebb7551cade7f5237d","host_type":"repository"}],"fields_of_study":["Epigenetics and DNA Methylation","Cancer-related gene regulation","Advanced Glycation End Products research","Humans","DNA Methylation","Carrier Proteins","Male","Female","Longitudinal Studies","Middle Aged","Blood Glucose","Glycated Hemoglobin","Adult","Diabetes Mellitus, Type 2","Aged","Leukocytes"],"mesh_terms":["Adult","Aged","Blood Glucose","Carrier Proteins","Diabetes Mellitus, Type 2","Female","Glycated Hemoglobin","Humans","Leukocytes","Longitudinal Studies","Male","Middle Aged","DNA Methylation"],"keywords":["TXNIP","dNaM","DNA methylation","Glycemic","Internal medicine","Odds ratio","Thioredoxin-Interacting Protein","Endocrinology","Biomarker","Biology","Glucose homeostasis","Medicine","Methylation","Epigenetics","Diabetes mellitus","Oncology","Genetics","Insulin resistance","DNA","Oxidative stress","Gene","Thioredoxin","Gene expression","Glucose","Type 2 Diabetes (T2dm)","Thioredoxin-interacting Protein (Txnip)","Hemoglobin A1c (Hba1c)","Dna Methylation (Dnam)"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T07:32:23.191038Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}