{"doi":"10.14814/phy2.16149","title":"The effect of endothelin a receptor inhibition and biological sex on cutaneous microvascular function in non‐Hispanic Black and White young adults","abstract":"Abstract The purpose of this study was to investigate whether endothelin‐A receptor (ET A R) inhibition in non‐Hispanic Black (NHB) and White (NHW) young adults depends on biological sex. We recruited females during low hormone ( n = 22) and high hormone ( n = 22) phases, and males ( n = 22). Participants self‐identified as NHB ( n = 33) or NHW ( n = 33). Participants were instrumented with two microdialysis fibers: (1) lactated Ringer's (control) and (2) 500 nM BQ‐123 (ET A R antagonist). Local heating was used to elicit cutaneous vasodilation, and an infusion of 20 mM L‐NAME to quantify NO‐dependent vasodilation. At control sites, NO‐dependent vasodilation was lowest in NHB males (46 ± 13 %NO) and NHB females during low hormone phases (47 ± 12 %NO) compared to all NHW groups. Inhibition of ET A R increased NO‐dependent vasodilation in NHB males (66 ± 13 %NO), in both groups of females during low hormone phases (NHW, control: 64 ± 12 %NO, BQ‐123: 85 ± 11 %NO; NHB, BQ‐123: 68 ± 13 %NO), and in NHB females during high hormone phases (control: 61 ± 11 %NO, BQ‐123: 83 ± 9 %NO). There was no effect for ET A R inhibition in NHW males or females during high hormone phases. These data suggest the effect of ET A R inhibition on NO‐dependent vasodilation is influenced by biological sex and racial identity.","journal":"Physiological Reports","year":2024,"id":478931,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9433,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371116,"name":"Matthew J. Hayat","orcid":"0000-0002-3252-2255","position":1,"is_corresponding":false},{"id":371114,"name":"Jeffrey S. Otis","orcid":"0000-0003-1215-9177","position":2,"is_corresponding":false},{"id":445436,"name":"Anurag Mehta","orcid":"0000-0002-6910-5551","position":3,"is_corresponding":false},{"id":371117,"name":"Brett J. Wong","orcid":"0000-0002-4763-0208","position":4,"is_corresponding":false},{"id":371113,"name":"Casey G. Turner","orcid":"0000-0001-8677-5912","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T02:06:46.330532Z","pmid":"39016164","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}