{"doi":"10.14814/phy2.15936","title":"Effect of histamine‐receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study","abstract":"Abstract The purpose of this study was to gain insight into histamine's role in the exercise inflammatory response and recovery from exercise. To explore this, young healthy participants ( n = 12) performed 300 eccentric leg extensions under control (Placebo) versus histamine H 1 and H 2 receptor antagonism (Blockade) in a randomized cross‐over study. Circulating leukocytes and cytokines were measured for 72 h after exercise. Circulating leukocytes were elevated at 6 and 12 h after exercise ( p < 0.05) with the peak response being a 44.1 ± 11.7% increase with Blockade versus 13.7 ± 6.6% with Placebo (both p < 0.05 vs. baseline, but also p < 0.05 between Blockade and Placebo). Of the cytokines that were measured, only MCP‐1 was elevated following exercise. The response at 6 h post‐exercise was a 104.0 ± 72.5% increase with Blockade versus 93.1 ± 41.9% with Placebo (both p < 0.05 vs. baseline, p = 0.82 between Blockade and Placebo). The main findings of the present investigation were that taking combined histamine H 1 and H 2 receptor antagonists augmented the magnitude but not the duration of the increase of circulating immune cells following exercise. This suggests histamine is not only exerting a local influence within the skeletal muscle but that it may influence the systemic inflammatory patterns.","journal":"Physiological Reports","year":2024,"id":448320,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1266935,"name":"Joshua E. Mangum","orcid":"0000-0001-9118-0382","position":1,"is_corresponding":false},{"id":1050554,"name":"Karen Wiedenfeld Needham","orcid":"0009-0005-0886-0544","position":2,"is_corresponding":false},{"id":699347,"name":"Christopher T. Minson","orcid":"0000-0003-3459-3708","position":3,"is_corresponding":false},{"id":383697,"name":"John R. Halliwill","orcid":"0000-0003-3001-1715","position":4,"is_corresponding":false},{"id":383693,"name":"Matthew R. Ely","orcid":"0000-0002-0618-7078","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:02:08.018689Z","pmid":"38307711","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}