{"doi":"10.14670/hh-29.10.497","title":"Unknown","abstract":null,"journal":null,"year":null,"id":672036,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"M1- and M2-macrophage polarization in thioacetamide (TAA)-induced rat liver lesions; a possible analysis for hepato-pathology.","abstract":"\"Classically activated macrophages (M1)\" and \"alternatively activated macrophages (M2)\", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats by a single injection of TAA (300 mg/kg BW), and liver samples were collected on post injection (PI) hour 10 and days 1 to 10. Macrophage immunophenotypes were analyzed by single and double immunolabeling. M1-/M2-related factors were analyzed by real-time RT-PCR. On PI hour 10 (when centrilobular lesions were not still developed), expressions of IFN-γ, TNF-α, IL-1β, and IL-6 for M1, and IL-4 for M2 were already increased, followed by increased expressions of IL-10 and TGF-β1 for M2 on PI days 1-3 with development of centrilobular lesions and subsequent reparative fibrosis. On PI hour 10, CD204⁺ and MHC class II⁺ macrophages already increased in the intact periportal/Glisson's sheath regions, accompanied by an increased number of granzyme B⁺ NK cells. Reactive cells at PI hour 10 might produce M1-related factors. In addition to these macrophages, CD68⁺ and CD163⁺ macrophages, and CD3⁺ T cells appeared in the injured centrilobular region on PI days 1-3; there were macrophages reacting simultaneously to CD68/MHC class II, CD163/MHC class II, CD68/CD204, CD163/CD204, and MHC class II/CD204 in varying degrees. Although CD68⁺ and CD163⁺ macrophages are regarded as M1- and M2-types, respectively, the double labeling indicated that macrophage immunophenotypes are interchangeable in injured regions and subsequent fibrosis. An M1-/M2-macrophage paradigm would be useful to analyze hepatotoxicity and to understand the pathogenesis.","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24127400","pmcid":null,"openalex_id":"https://openalex.org/W1597108961","authors":[],"funders":[],"total_grants":0,"fwci":5.7532,"citation_percentile":0.95144427,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":7},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"http://hdl.handle.net/10201/67909","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24127400","host_type":"repository"}],"fields_of_study":["Drug-Induced Hepatotoxicity and Protection","Liver physiology and pathology","Liver Disease Diagnosis and Treatment","Animals","Chemical and Drug Induced Liver Injury","Fluorescent Antibody Technique","Immunophenotyping","Inflammation","Macrophages","Male","Rats, Inbred F344","Real-Time Polymerase Chain Reaction","Reverse Transcriptase Polymerase Chain Reaction","Thioacetamide"],"mesh_terms":["Animals","Fluorescent Antibody Technique","Inflammation","Macrophages","Male","Rats, Inbred F344","Thioacetamide","Immunophenotyping","Reverse Transcriptase Polymerase Chain Reaction","Chemical and Drug Induced Liver Injury","Real-Time Polymerase Chain Reaction"],"keywords":["CD68","CD163","Macrophage","M2 Macrophage","Macrophage polarization","MHC class II","Pathology","Inflammation","Chemistry","Medicine","Immunology","Biology","Molecular biology","Immunohistochemistry","Major histocompatibility complex","Immune system","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14252167.v1","title":"Additional file 1 of Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14252167","title":"Additional file 1 of Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T06:04:41.763269Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}