{"doi":"10.14336/ad.2022.1220","title":"Aging, Plasminogen Activator Inhibitor 1, Brain Cell Senescence, and Alzheimer's Disease.","abstract":"-induced senescence, in primary mouse and human astrocytes. Treatment with the conditional medium (CM) from senescent astrocytes induced neuron apoptosis. Importantly, the PAI-1 deficient CM from senescent astrocytes that overexpress a secretion deficient PAI-1 (sdPAI-1) has significantly reduced effect on neurons, compared to the PAI-1 containing CM from senescent astrocytes overexpressing wild type PAI-1 (wtPAI-1), although sdPAI-1 and wtPAI-1 induce similar degree of astrocyte senescence. Together, our results suggest that increased PAI-1, intracellularly or extracellularly, may contribute to brain cell senescence in LOAD and that senescent astrocytes can induce neuron apoptosis through secreting pathologically active molecules, including PAI-1.","journal":"PubMed","year":2023,"id":333768,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1062174,"name":"Tapasi Rana","orcid":null,"position":1,"is_corresponding":false},{"id":585338,"name":"Lee‐Way Jin","orcid":"0000-0001-9729-1032","position":2,"is_corresponding":false},{"id":603382,"name":"Susan A. Farr","orcid":"0000-0002-0481-2570","position":3,"is_corresponding":false},{"id":273976,"name":"John E. Morley","orcid":"0000-0003-1104-0393","position":4,"is_corresponding":false},{"id":479702,"name":"Hongwei Qin","orcid":"0000-0002-7511-5078","position":5,"is_corresponding":false},{"id":276038,"name":"Gang Liu","orcid":"0000-0003-2615-131X","position":6,"is_corresponding":false},{"id":228867,"name":"Rui-Ming Liu","orcid":"0000-0003-0281-6102","position":7,"is_corresponding":false},{"id":707031,"name":"Chunsun Jiang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:09:44.297718Z","pmid":"37008063","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}