{"doi":"10.14283/jpad.2022.58","title":"Everyday Functioning and Entorhinal and Inferior Temporal Tau Burden in Cognitively Normal Older Adults","abstract":"BACKGROUND: Performance of cognitively complex \"instrumental activities of daily living\" (IADL) has previously been related to amyloid deposition in preclinical Alzheimer's disease. OBJECTIVES: We aimed to investigate the relationship between IADL performance and cerebral tau accumulation in cognitively normal older adults. DESIGN: Cross-sectional. SETTING: Data was collected in the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies. PARTICIPANTS: Participants (n = 447, age 71.9±4.9 years, 57.5% female) who underwent tau positron emission tomography were selected from the A4 and LEARN studies. MEASUREMENTS: IADL performance was measured using the self- and study partner-reported versions of the Alzheimer's Disease Cooperative Study Activities of Daily Living - Prevention Instrument (ADCS ADL-PI). We also investigated discordance between participants and their study partners. Cross-sectional associations between entorhinal and inferior temporal tau (independent variables) and ADCS ADL-PI total scores, item-level scores and discordance (dependent variables) were investigated in linear and logistic regressions. Analyses were adjusted for age, sex and education and a tau by amyloid interaction was also included. RESULTS: Participants and their study partners reported high levels of IADL performance. Entorhinal and inferior temporal tau were related to study partner but not to self-reported total ADCS ADL-PI scores. The association was not retained after adjustment for global cerebral amyloid burden. At the item level, greater entorhinal tau was associated with study partner-reported difficulties remembering important dates (odds ratio (OR) = 1.24, 95% confidence interval (95%CI) = [1.06, 1.45], p = 0.008) and difficulties remembering the details of TV programs and movies (OR = 1.32, 95%CI = [1.08, 1.61], p = 0.007). Greater inferior temporal tau was associated with self-reported difficulties managing to find personal belongings (OR = 1.23, 95%CI = [1.04, 1.46], p = 0.018) and study partner-reported difficulties remembering the details of TV programs and movies (OR = 1.39, 95%CI = [1.11, 1.75], p = 0.005). Discordance between participant and study partner-report was more likely with greater entorhinal (OR = 1.18, 95%CI = [1.05, 1.33], p = 0.005) and inferior temporal tau burden (OR = 1.29, 95%CI = [1.10, 1.51], p = 0.002). DISCUSSION: We found a cross-sectional relationship between study partner-reported everyday functioning and tau in cognitively normal older adults. Participants were more likely to self-report difficulties differently from their study partners when tau burden was higher. This may hint at an altered early-disease awareness of functional changes and underscores the importance of self-report of IADL functioning in addition to collateral report by a study partner.","journal":"The Journal of Prevention of Alzheimer s Disease","year":2022,"id":261111,"datarank":0.6302043507293394,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.2143160423933722,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.2143160423933722,"corpus_percentile":68.61607488202986,"corpus_rank":4058,"citation_count":15,"citer_count":11,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.58,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":180118,"name":"J. Sanchez","orcid":null,"position":1,"is_corresponding":false},{"id":915311,"name":"A.P. Schultz","orcid":"0000-0003-0519-066X","position":2,"is_corresponding":false},{"id":915920,"name":"D.M. Rentz","orcid":null,"position":3,"is_corresponding":false},{"id":915921,"name":"R.E. Amariglio","orcid":null,"position":4,"is_corresponding":false},{"id":282466,"name":"Sietske A.M. Sikkes","orcid":"0000-0002-0161-3656","position":5,"is_corresponding":false},{"id":365219,"name":"R.A. Sperling","orcid":null,"position":6,"is_corresponding":false},{"id":94135,"name":"K.A. Johnson","orcid":"0000-0001-6781-0831","position":7,"is_corresponding":false},{"id":313455,"name":"Gad A. Marshall","orcid":"0000-0002-9096-2355","position":8,"is_corresponding":false},{"id":899425,"name":"Mark A. Dubbelman","orcid":"0000-0002-5708-4925","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:26:12.158801Z","pmid":"36281685","pmcid":"PMC10308613","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}