{"doi":"10.1378/chest.15-1061","title":"Ordering of the Serum Angiotensin-Converting Enzyme Test in Patients Receiving Angiotensin-Converting Enzyme Inhibitor Therapy","abstract":null,"journal":"Chest","year":2015,"id":618790,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1596577,"name":"Johanna Savage","orcid":null,"position":1,"is_corresponding":false},{"id":1596578,"name":"Alexandra Ehlers","orcid":null,"position":2,"is_corresponding":false},{"id":1596579,"name":"Jon Maakestad","orcid":null,"position":3,"is_corresponding":false},{"id":400162,"name":"Gregory A. Schmidt","orcid":"0000-0002-5013-6323","position":4,"is_corresponding":false},{"id":1596580,"name":"Sonia La'ulu","orcid":null,"position":5,"is_corresponding":false},{"id":1596581,"name":"Natalie N. Rasmussen","orcid":null,"position":6,"is_corresponding":false},{"id":1596582,"name":"Frederick G. Strathmann","orcid":null,"position":7,"is_corresponding":false},{"id":518146,"name":"Jonathan R. Genzen","orcid":"0000-0002-7219-0259","position":8,"is_corresponding":false},{"id":611817,"name":"Matthew D. Krasowski","orcid":"0000-0003-0856-8402","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ordering of the Serum Angiotensin-Converting Enzyme Test in Patients Receiving Angiotensin-Converting Enzyme Inhibitor Therapy","abstract":"<h4>Background</h4>Serum angiotensin-converting enzyme (ACE) levels may be decreased by use of ACE inhibitor (ACEI) medication. In this study, we determined how often ACE levels were measured in patients receiving ACEI therapy.<h4>Methods</h4>ACE levels analyzed over a 54-month preintervention time period at an academic medical center were reviewed retrospectively for tests performed during ACEI therapy. These data were compared with a large, deidentified dataset of ACE levels measured at a national reference laboratory; in vitro studies of ACEI inhibition; and liquid chromatography time-of-flight mass spectrometry detection of lisinopril in a subset of clinical specimens.<h4>Results</h4>Over a 54-month period, 1,292 patients had ACE levels measured, with 108 patients (8.4%) receiving ACEI therapy at the time of testing. ACE levels measured for patients receiving ACEI therapy were substantially lower. In general, clinical teams did not recognize a medication effect on ACE levels. Introduction of a warning prompt in the electronic health record reduced the ordering of ACE levels in patients receiving ACEIs by > 60% in a 17-month postintervention time period. The deidentified dataset of ACE levels at a reference laboratory showed a bimodal distribution, with a peak of very low ACE levels. Using liquid chromatography time-of-flight mass spectrometry, the presence of lisinopril was confirmed in a subset of specimens with low ACE activity. In vitro studies of two different ACE assays showed significant inhibition of activity at clinically relevant concentrations.<h4>Conclusions</h4>Assessment of ACE activity is often measured for patients receiving ACEIs, potentially leading to low ACE concentrations and inaccurate interpretations.","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26225637","pmcid":null,"openalex_id":"https://openalex.org/W2186768350","authors":[],"funders":[],"total_grants":0,"fwci":1.6002,"citation_percentile":0.84879333,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":5},{"year":2021,"count":6},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0012369215501086?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012369215501086?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1378/chest.15-1061","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26225637","host_type":"repository"}],"fields_of_study":["Renin-Angiotensin System Studies","Blood Pressure and Hypertension Studies","Protein Hydrolysis and Bioactive Peptides"],"mesh_terms":["Adult","Aged","Angiotensin-Converting Enzyme Inhibitors","Biological Availability","Cardiovascular Diseases","Diagnostic Errors","Female","Humans","Peptidyl-Dipeptidase A","Male","Middle Aged","Retrospective Studies","Sarcoidosis","United States","Lisinopril"],"keywords":["Lisinopril","Medicine","ACE inhibitor","Angiotensin-converting enzyme","Internal medicine","Pharmacology","Blood pressure"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T05:17:17.443376Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}