{"doi":"10.1378/chest.118.3.656","title":"Pulmonary Function Is a Long-term Predictor of Mortality in the General Population","abstract":"<h4>Study objectives</h4>Results from several studies have described a relationship between pulmonary function and both all-cause and cause-specific mortality. The purpose of this study was to investigate the predictive value of pulmonary function by gender after 29 years of follow-up.<h4>Design</h4>Prospective study with 29-year follow-up of the Buffalo Health Study cohort.<h4>Participants</h4>Randomly selected sample of 554 men and 641 women, aged 20 to 89 years, from all listed households of the city of Buffalo, NY.<h4>Measurements and results</h4>Baseline measurements were performed in 1960 to 1961. Pulmonary function was assessed based on FEV(1) expressed as the normal percent predicted (FEV(1)%pred). FEV(1)%pred adjusted by age, body mass index, systolic BP, education, and smoking status was inversely related to all-cause mortality in both men and women (p<0.01). A sequential survival analysis in participants who had a survival time of at least 5, 10, 15, 20, and 25 years after enrollment in the study was also performed. Except for men who survived for > 25 years, we observed a statistically significant negative association between FEV(1)%pred and all-cause mortality. FEV(1)%pred was also inversely related to ischemic heart disease (IHD) mortality. When participants were divided into quintiles of FEV(1)%pred, participants in the lowest quintile of FEV(1)%pred experienced significantly higher all-cause mortality compared with participants in the highest quintile of FEV(1)%pred. For the entire follow-up period, the adjusted hazard ratios for all-cause mortality were 2.24 (95% confidence interval [CI], 1.60 to 3.13) for men and 1. 81 (95% CI, 1.24 to 2.63) for women, respectively. Hazard ratios for death from IHD in the lowest quintile of FEV(1)%pred were 2.11 (95% CI, 1.20 to 3.71) and 1.96 (95% CI, 0.99 to 3.88) for men and women, respectively.<h4>Conclusions</h4>These results suggest that pulmonary function is a long-term predictor for overall survival rates in both genders and could be used as a tool in general health assessment.","journal":"Chest","year":2000,"id":5123,"datarank":0.9617727401564847,"base_score":6.411818267709897,"endowment":6.411818267709897,"self_citation_contribution":0.9617727401564847,"citation_network_contribution":0.0,"self_endowment_contribution":0.9617727401564847,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":608,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.1028,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2000-09-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":51954,"name":"Joan Dorn","orcid":null,"position":1,"is_corresponding":false},{"id":51955,"name":"Brydon J.B. Grant","orcid":null,"position":2,"is_corresponding":false},{"id":51956,"name":"Warren Winkelstein","orcid":null,"position":3,"is_corresponding":false},{"id":51957,"name":"Maurizio Trevisan","orcid":"0000-0001-5479-0050","position":4,"is_corresponding":false},{"id":51958,"name":"Brydon J. B. Grant","orcid":null,"position":5,"is_corresponding":false},{"id":51953,"name":"Holger J. Schu ̈nemann","orcid":null,"position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}