{"doi":"10.1371/journal.ppat.1012854","title":"An interferon-stimulated long non-coding RNA USP30-AS1 as an immune modulator in influenza A virus infection","abstract":"Long non-coding RNAs (lncRNAs) are essential components of innate immunity, maintaining the functionality of immune systems that control virus infection. However, how lncRNAs engage immune responses during influenza A virus (IAV) infection remains unclear. Here, we show that lncRNA USP30-AS1 is up-regulated by infection of multiple different IAV subtypes and is required for tuning inflammatory and antiviral response in IAV infection. Genetically inactivation of USP30-AS1 enhances viral protein synthesis and viral growth. USP30-AS1 is an interferon-stimulated gene, and the induction of USP30-AS1 can be achieved by JAK-STAT mediated signaling activation. The immune regulation of USP30-AS1 is independent of its proximal protein-coding gene USP30. In IAV infection, deletion of USP30-AS1 unleashes high systemic inflammatory responses involving a broad range of pro-inflammatory factors, suggesting USP30-AS1 as a critical modulator of immune responses in IAV infection. Furthermore, we established a database providing well-annotated host gene expression profiles IAV infection or immune stimulation.","journal":"PLoS Pathogens","year":2025,"id":511133,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104946,"name":"Alex W. H. Chin","orcid":"0000-0002-6556-9092","position":1,"is_corresponding":false},{"id":326917,"name":"Haogao Gu","orcid":"0000-0002-7541-4262","position":2,"is_corresponding":false},{"id":1368393,"name":"Mengting Li","orcid":"0000-0002-0144-870X","position":3,"is_corresponding":false},{"id":1368990,"name":"Yuner Gu","orcid":null,"position":4,"is_corresponding":false},{"id":384419,"name":"Sylvia P. N. Lau","orcid":null,"position":5,"is_corresponding":false},{"id":104948,"name":"Kenrie P. Y. Hui","orcid":"0000-0003-1506-0535","position":6,"is_corresponding":false},{"id":104950,"name":"Michael C. W. Chan","orcid":"0000-0001-8174-8405","position":7,"is_corresponding":false},{"id":77539,"name":"Leo L. M. Poon","orcid":"0000-0002-9101-7953","position":8,"is_corresponding":false},{"id":1196076,"name":"Yi Cao","orcid":"0000-0002-4165-4030","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:47:50.575618Z","pmid":"39777915","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}