{"doi":"10.1371/journal.ppat.1012661","title":"Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens","abstract":"Plasmodium falciparum infections elicit strong humoral immune responses to two main groups of antigens expressed by blood-stage parasites: merozoite antigens that are involved in the erythrocyte invasion process and variant surface antigens that mediate endothelial sequestration of infected erythrocytes. Long-lived B cells against both antigen classes can be detected in the circulation for years after exposure, but have not been directly compared. Here, we studied the phenotype of long-lived memory and atypical B cells to merozoite antigens (MSP1 and AMA1) and variant surface antigens (the CIDRα1 domain of PfEMP1) in ten Ugandan adults before and after local reduction of P. falciparum transmission. After a median of 1.7 years without P. falciparum infections, the percentage of antigen-specific activated B cells declined, but long-lived antigen-specific B cells were still detectable in all individuals. The majority of MSP1/AMA1-specific B cells were CD95+CD11c+ memory B cells, which are primed for rapid differentiation into antibody-secreting cells, and FcRL5-T-bet- atypical B cells. On the other hand, most CIDRα1-specific B cells were CD95-CD11c- memory B cells. CIDRα1-specific B cells were also enriched among a subset of atypical B cells that seem poised for antigen presentation. These results point to differences in how these antigens are recognized or processed by the immune system and how P. falciparum-specific B cells will respond upon re-infection.","journal":"PLoS Pathogens","year":2024,"id":472270,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":260436,"name":"Louise Turner","orcid":"0000-0003-4494-2289","position":1,"is_corresponding":false},{"id":425680,"name":"Isaac Ssewanyana","orcid":"0000-0001-8605-2001","position":2,"is_corresponding":false},{"id":233149,"name":"Prasanna Jagannathan","orcid":"0000-0001-6305-758X","position":3,"is_corresponding":false},{"id":443234,"name":"Margaret E. Feeney","orcid":"0000-0002-2515-2989","position":4,"is_corresponding":false},{"id":260442,"name":"Thomas Lavstsen","orcid":"0000-0002-3044-4249","position":5,"is_corresponding":false},{"id":299001,"name":"Bryan Greenhouse","orcid":"0000-0003-0287-9111","position":6,"is_corresponding":false},{"id":290733,"name":"Sebastiaan Bol","orcid":"0000-0002-3843-6657","position":7,"is_corresponding":false},{"id":290734,"name":"Evelien M. Bunnik","orcid":"0000-0003-4003-3053","position":8,"is_corresponding":false},{"id":290731,"name":"Raphael A. Reyes","orcid":"0000-0002-2234-4758","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:05:53.032464Z","pmid":"39466842","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}