{"doi":"10.1371/journal.ppat.1012616","title":"8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus","abstract":"Respiratory syncytial virus (RSV), along with other prominent respiratory RNA viruses such as influenza and SARS-CoV-2, significantly contributes to the global incidence of respiratory tract infections. These pathogens induce the production of reactive oxygen species (ROS), which play a crucial role in the onset and progression of respiratory diseases. However, the mechanisms by which viral RNA manages ROS-induced base oxidation remain poorly understood. Here, we reveal that 8-oxo-7,8-dihydroguanine (8-oxoGua) is not merely an incidental byproduct of ROS activity but serves as a strategic adaptation of RSV RNA to maintain genetic fidelity by hijacking the 8-oxoguanine DNA glycosylase 1 (OGG1). Through RNA immunoprecipitation and next-generation sequencing, we discovered that OGG1 binding sites are predominantly found in the RSV antigenome, especially within guanine-rich sequences. Further investigation revealed that viral ribonucleoprotein complexes specifically exploit OGG1. Importantly, inhibiting OGG1's ability to recognize 8-oxoGua significantly decreases RSV progeny production. Our results underscore the viral replication machinery's adaptation to oxidative challenges, suggesting that inhibiting OGG1's reading function could be a novel strategy for antiviral intervention.","journal":"PLoS Pathogens","year":2024,"id":466557,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1298710,"name":"Ke Wang","orcid":"0000-0003-1156-5296","position":1,"is_corresponding":false},{"id":826384,"name":"Wenjing Hao","orcid":"0000-0002-8487-5968","position":2,"is_corresponding":false},{"id":1107687,"name":"Yaoyao Xue","orcid":"0000-0003-2137-6181","position":3,"is_corresponding":false},{"id":1107688,"name":"Xu Zheng","orcid":"0000-0001-5523-7177","position":4,"is_corresponding":false},{"id":379031,"name":"Ritwika Basu","orcid":"0000-0001-6410-7905","position":5,"is_corresponding":false},{"id":348403,"name":"Tapas K. Hazra","orcid":"0000-0002-4587-687X","position":6,"is_corresponding":false},{"id":687792,"name":"Azharul Islam","orcid":"0000-0003-4958-5057","position":7,"is_corresponding":false},{"id":990252,"name":"Yashoda Madaiah Hosakote","orcid":"0000-0001-8981-2264","position":8,"is_corresponding":false},{"id":396906,"name":"Bing Tian","orcid":"0000-0002-5497-1158","position":9,"is_corresponding":false},{"id":826386,"name":"Matthieu G. Gagnon","orcid":"0000-0003-4516-604X","position":10,"is_corresponding":false},{"id":826388,"name":"Xueqing Ba","orcid":"0000-0002-1075-5496","position":11,"is_corresponding":false},{"id":724067,"name":"István Boldogh","orcid":"0000-0002-0088-1130","position":12,"is_corresponding":false},{"id":826385,"name":"Lang Pan","orcid":"0000-0003-2324-2144","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:05:06.743102Z","pmid":"39413143","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}