{"doi":"10.1371/journal.ppat.1012191","title":"CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection","abstract":"An imbalance between suppressor and effector immune responses may preclude cure in chronic parasitic diseases. In the case of Trypanosoma cruzi infection, specialized regulatory Foxp3+ T (Treg) cells suppress protective type-1 effector responses. Herein, we investigated the kinetics and underlying mechanisms behind the regulation of protective parasite-specific CD8+ T cell immunity during acute T. cruzi infection. Using the DEREG mouse model, we found that Treg cells play a role during the initial stages after T. cruzi infection, restraining the magnitude of CD8+ T cell responses and parasite control. Early Treg cell depletion increased the frequencies of polyfunctional short-lived, effector T cell subsets, without affecting memory precursor cell formation or the expression of activation, exhaustion and functional markers. In addition, Treg cell depletion during early infection minimally affected the antigen-presenting cell response but it boosted CD4+ T cell responses before the development of anti-parasite effector CD8+ T cell immunity. Crucially, the absence of CD39 expression on Treg cells significantly bolstered effector parasite-specific CD8+ T cell responses, preventing increased parasite replication in T. cruzi infected mice adoptively transferred with Treg cells. Our work underscores the crucial role of Treg cells in regulating protective anti-parasite immunity and provides evidence that CD39 expression by Treg cells represents a key immunomodulatory mechanism in this infection model.","journal":"PLoS Pathogens","year":2024,"id":455761,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1050065,"name":"Santiago Boccardo","orcid":null,"position":1,"is_corresponding":false},{"id":490459,"name":"Constanza Rodríguez","orcid":"0000-0001-9578-495X","position":2,"is_corresponding":false},{"id":1279854,"name":"Verónica S. Mary","orcid":"0009-0003-1623-3511","position":3,"is_corresponding":false},{"id":1280257,"name":"Camila M. S. Giménez","orcid":null,"position":4,"is_corresponding":false},{"id":255723,"name":"Simon C. Robson","orcid":"0000-0001-6374-0194","position":5,"is_corresponding":false},{"id":490460,"name":"Adriana Gruppi","orcid":"0000-0002-8034-9303","position":6,"is_corresponding":false},{"id":492388,"name":"Carolina L. Montes","orcid":"0000-0003-0494-1820","position":7,"is_corresponding":false},{"id":490461,"name":"Eva V. Acosta Rodríguez","orcid":"0000-0001-5871-2391","position":8,"is_corresponding":false},{"id":1050064,"name":"Cintia L. Araujo Furlan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":null,"created_at":"2026-07-19T02:03:22.974789Z","pmid":"38683845","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}