{"doi":"10.1371/journal.ppat.1011845","title":"New anticancer therapeutics impact fungal pathobiology, infection dynamics, and outcome","abstract":"Fungal infections are significant public health concerns, with an estimated 1 billion cases and 1.6 million deaths per year worldwide Many life-threatening fungal infections develop in immunocompromised individuals with conditions such as HIV, solid organ transplantation, and cancer. Chemotherapy-induced immune suppression is frequently associated with opportunistic fungal infections, often through drug-induced neutropenia and mucositis Even new targeted therapeutics, such as Burton's tyrosine kinase (BTK) inhibitors, have been found to predispose cancer patients to fungal infections. While frustrating to clinicians, researchers can use cases of targeted therapy-associated fungal infections to better understand the complex relationship between the fungal pathogen and human host. Alternately, certain anticancer agents have been found to possess inherent antifungal properties. As eukaryotic diseases, cancer and fungal infections present both challenges and opportunities for novel treatments. Even in an era of targeted and precision medicine, opportunistic fungal infections are likely to remain a major factor affecting patient outcome. There is a continued need to uncover the factors influencing treatment-associated infection susceptibility and to identify potential opportunities for drug repurposing.","journal":"PLoS Pathogens","year":2023,"id":378225,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108849,"name":"Julia A. Messina","orcid":"0000-0001-6411-198X","position":1,"is_corresponding":false},{"id":419588,"name":"Jennifer L. Tenor","orcid":"0000-0002-1463-7243","position":2,"is_corresponding":false},{"id":419592,"name":"John R. Perfect","orcid":"0000-0002-8742-3676","position":3,"is_corresponding":false},{"id":815398,"name":"Julia R. Palmucci","orcid":"0000-0001-6343-8278","position":0,"is_corresponding":true}],"reference_count":104,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:16:44.708019Z","pmid":"38127685","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}