{"doi":"10.1371/journal.ppat.1011333","title":"Prions are the greatest protein misfolding problem, and yeast has several solutions","abstract":"Prion\" means \"infectious protein,\" with no nucleic acid required for transmission. Most prions involve self-propagating misfolding, usually amyloid (a filamentous polymer of a single protein rich in -sheet). Prions are only one kind of misfolded protein, but they pose a much greater danger to the individual or species than other forms of misfolding because they are infectious. When a non-prion protein misfolds, it is only a problem for that molecule. A single event of prion formation can conceivably eliminate an individual, a population of a species, or even the entire species. This results in strong selection pressure for the cells/animals that have defenses against prions. Yeast anti-prion systems lower prion generation, cure nearly all prions that do arise, block prion infection, and mitigate prion pathology (Fig Fig 1. Anti-prion systems block infection, generation, segregation, propagation, and pathogenic effects of most prions.","journal":"PLoS Pathogens","year":2023,"id":352547,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":776912,"name":"Herman K. Edskes","orcid":"0000-0002-2708-2961","position":1,"is_corresponding":false},{"id":1098402,"name":"Songsong Wu","orcid":"0009-0004-6083-4821","position":2,"is_corresponding":false},{"id":1098897,"name":"Kristen Gregg","orcid":null,"position":3,"is_corresponding":false},{"id":370849,"name":"Reed B. Wickner","orcid":"0000-0003-0273-8247","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T01:12:54.209378Z","pmid":"37141188","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}