{"doi":"10.1371/journal.ppat.1010782","title":"SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice","abstract":"Safe, passive immunization methods are required against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants. Immunization of chickens with antigen is known to induce specific IgY antibodies concentrated in the egg yolk and has a good safety profile, high yield of IgY per egg, can be topically applied, not requiring parenteral delivery. Our data provide the first evidence of the prophylactic efficacy of Immunoglobulin Y antibodies against SARS-CoV-2 in mice. Lohmann hens were injected with recombinant SARS-CoV-2 RBD protein; IgY-Abs were extracted from the eggs and characterized using SDS-PAGE. Antiviral activity was evaluated using plaque reduction neutralization tests. In additional experiments, IgY-RBD efficacy was examined in mice sensitized to SARS-CoV-2 infection by transduction with Ad5-hACE2 (mild disease) or by using mouse-adapted virus (severe disease). In both cases, prophylactic intranasal administration of IgY-Abs reduced SARS-CoV-2 replication, and reduced morbidity, inflammatory cell infiltration, hemorrhage, and edema in the lungs and increased survival compared to control groups that received non-specific IgY-Abs. These results indicate that further evaluation of IgY-RBD antibodies in humans is warranted.","journal":"PLoS Pathogens","year":2022,"id":254724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553733,"name":"Abby Odle","orcid":"0000-0003-0526-9503","position":1,"is_corresponding":false},{"id":901886,"name":"Aymn T. Abbas","orcid":"0000-0001-7372-370X","position":2,"is_corresponding":false},{"id":570360,"name":"Ahmed M. Hassan","orcid":"0009-0002-7989-0466","position":3,"is_corresponding":false},{"id":902430,"name":"Umama A. Abdel-dayem","orcid":null,"position":4,"is_corresponding":false},{"id":902431,"name":"Arooj K. Qureshi","orcid":null,"position":5,"is_corresponding":false},{"id":360688,"name":"Lok-Yin Roy Wong","orcid":"0000-0002-0727-8289","position":6,"is_corresponding":false},{"id":227005,"name":"Jian Zheng","orcid":"0000-0003-0909-128X","position":7,"is_corresponding":false},{"id":227015,"name":"David K. Meyerholz","orcid":"0000-0003-1552-3253","position":8,"is_corresponding":false},{"id":77538,"name":"Stanley Perlman","orcid":"0000-0003-4213-2354","position":9,"is_corresponding":false},{"id":85550,"name":"Alimuddin Zumla","orcid":"0000-0002-5111-5735","position":10,"is_corresponding":false},{"id":228080,"name":"Esam I. Azhar","orcid":"0000-0002-1736-181X","position":11,"is_corresponding":false},{"id":551747,"name":"Sherif A. El‐Kafrawy","orcid":"0000-0002-3667-7529","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T00:25:08.518416Z","pmid":"36121829","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}