{"doi":"10.1371/journal.ppat.1010726","title":"HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy","abstract":"Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for understanding the stability of the reservoir; however, the stabilities of clones of infected T cells in persons on long-term ART are not well defined. We determined the relative stabilities of clones of infected and uninfected CD4+ T cells over time intervals of one to four years in three individuals who had been on ART for 9-19 years. The largest clones of uninfected T cells were larger than the largest clones of infected T cells. Clones of infected CD4+ T cells were more stable than clones of uninfected CD4+ T cells of a similar size. Individual clones of CD4+ T cells carrying intact, infectious proviruses can expand, contract, or remain stable over time.","journal":"PLoS Pathogens","year":2022,"id":259016,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":523887,"name":"Brian T. Luke","orcid":"0000-0002-2777-7376","position":1,"is_corresponding":false},{"id":619541,"name":"Amy R. Henry","orcid":null,"position":2,"is_corresponding":false},{"id":277146,"name":"Samuel Darko","orcid":"0000-0002-9711-8122","position":3,"is_corresponding":false},{"id":258956,"name":"Leah D. Brandt","orcid":"0000-0002-2007-933X","position":4,"is_corresponding":false},{"id":255120,"name":"Ling Su","orcid":"0000-0003-3880-7064","position":5,"is_corresponding":false},{"id":911087,"name":"David Sun","orcid":"0000-0001-9666-6824","position":6,"is_corresponding":false},{"id":351536,"name":"Daria Wells","orcid":"0000-0002-3475-3591","position":7,"is_corresponding":false},{"id":258955,"name":"Kevin W. Joseph","orcid":"0000-0001-7091-1588","position":8,"is_corresponding":false},{"id":911088,"name":"Dimiter Demirov","orcid":"0000-0002-6119-7199","position":9,"is_corresponding":false},{"id":258954,"name":"Elias K. Halvas","orcid":"0000-0002-4890-1209","position":10,"is_corresponding":false},{"id":277153,"name":"Daniel C. Douek","orcid":"0000-0001-5575-8634","position":11,"is_corresponding":false},{"id":255121,"name":"Xiaolin Wu","orcid":"0000-0002-6432-1300","position":12,"is_corresponding":false},{"id":258969,"name":"John W. Mellors","orcid":"0000-0002-3737-9742","position":13,"is_corresponding":false},{"id":258968,"name":"Stephen H. Hughes","orcid":"0000-0002-9176-4377","position":14,"is_corresponding":false},{"id":258957,"name":"Shuang Guo","orcid":"0000-0002-6837-7125","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T00:25:47.305414Z","pmid":"36044447","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}