{"doi":"10.1371/journal.ppat.1010536","title":"Fashionably late: Temporal regulation of HSV-1 late gene transcription","abstract":"Herpes simplex virus type-1 (HSV-1) is an alpha herpesvirus that infects over 60% of the human population Infection results in a variety of disease manifestations, including cold sores, encephalitis, and keratitis. The HSV-1 genome contains approximately 152 kb of doublestranded DNA and includes over 80 genes Recently, studies using direct RNA sequencing, long-read sequencing, and ribosome profiling have revealed the transcriptional complexity of the HSV-1 genome and demonstrate that the genome actually contains over 200 open reading frames Viral genes are classified into 4 groups depending on their expression kinetics, including immediate early (), early (), leaky-late ( 1 ), and true late ( 2 ) genes. HSV-1 DNA replication is a key point in the infectious cycle, as it enables 2 and amplifies 1 transcription Below, we discuss the studies that defined the 4 HSV-1 gene classes and examine how viral DNA replication may facilitate a switch to regulate ( 1 / 2 ) gene transcription. Although the HSV-1 gene expression cascade was identified over 40 years ago, high-throughput sequencing approaches continue to reveal new insight into how each gene class is regulated","journal":"PLoS Pathogens","year":2022,"id":248517,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9586,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":500511,"name":"Jill A. Dembowski","orcid":"0000-0002-0309-8053","position":1,"is_corresponding":false},{"id":888633,"name":"Joseph R. Heath","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T00:24:14.794521Z","pmid":"35709094","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}