{"doi":"10.1371/journal.ppat.1010352","title":"Scrambled or flipped: 5 facts about how cellular phosphatidylserine localization can mediate viral replication","abstract":"Host cell lipids are intimately involved in virus replication. Enveloped viruses are enshrouded in lipids from host cell membranes, shielding particles from the immune system and extracellular environment. Viruses can up-regulate cell lipid synthases to stimulate lipid production or recruit synthases to sites of viral replication. Furthermore, some viruses can induce autophagy to free stored lipids and optimize replication. Viruses can also remodel the composition of cell membranes, altering the concentration or localization of components such as sterols, sphingolipids, and phospholipids Here, we discuss virus-directed localization of phosphatidylserine (PtdSer), through host flippases and scramblases.","journal":"PLoS Pathogens","year":2022,"id":272491,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9422,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":227813,"name":"Melinda A. Brindley","orcid":"0000-0002-4929-8085","position":1,"is_corresponding":false},{"id":501436,"name":"Marissa D. Acciani","orcid":"0000-0001-6642-9772","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:27:47.926496Z","pmid":"35245334","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}