{"doi":"10.1371/journal.ppat.1010112","title":"Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide","abstract":"Hydrogen peroxide (H2O2) is the most common chemical threat that organisms face. Here, we show that H2O2 alters the bacterial food preference of Caenorhabditis elegans, enabling the nematodes to find a safe environment with food. H2O2 induces the nematodes to leave food patches of laboratory and microbiome bacteria when those bacterial communities have insufficient H2O2-degrading capacity. The nematode's behavior is directed by H2O2-sensing neurons that promote escape from H2O2 and by bacteria-sensing neurons that promote attraction to bacteria. However, the input for H2O2-sensing neurons is removed by bacterial H2O2-degrading enzymes and the bacteria-sensing neurons' perception of bacteria is prevented by H2O2. The resulting cross-attenuation provides a general mechanism that ensures the nematode's behavior is faithful to the lethal threat of hydrogen peroxide, increasing the nematode's chances of finding a niche that provides both food and protection from hydrogen peroxide.","journal":"PLoS Pathogens","year":2021,"id":192580,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":393801,"name":"Stephanie V. Stumbur","orcid":null,"position":1,"is_corresponding":false},{"id":759728,"name":"Maedeh Seyedolmohadesin","orcid":"0000-0003-3742-394X","position":2,"is_corresponding":false},{"id":392142,"name":"Yuyan Xu","orcid":"0000-0003-3335-1248","position":3,"is_corresponding":false},{"id":392143,"name":"William T. Serkin","orcid":"0000-0001-8551-5035","position":4,"is_corresponding":false},{"id":392140,"name":"Natalie McGowan","orcid":"0000-0002-5461-4986","position":5,"is_corresponding":false},{"id":759729,"name":"Oluwatosin Banjo","orcid":"0000-0003-0658-4150","position":6,"is_corresponding":false},{"id":759730,"name":"Mahdi Torkashvand","orcid":"0000-0002-4381-0367","position":7,"is_corresponding":false},{"id":233151,"name":"Albert Lin","orcid":"0000-0002-4541-5889","position":8,"is_corresponding":false},{"id":417177,"name":"Ciara N. Hosea","orcid":null,"position":9,"is_corresponding":false},{"id":247504,"name":"Adrien Assié","orcid":"0000-0003-3568-0766","position":10,"is_corresponding":false},{"id":247508,"name":"Buck S. Samuel","orcid":"0000-0002-4347-3997","position":11,"is_corresponding":false},{"id":724652,"name":"Michael P. O’Donnell","orcid":"0000-0001-8313-8969","position":12,"is_corresponding":false},{"id":233158,"name":"Vivek Venkatachalam","orcid":"0000-0002-2414-7416","position":13,"is_corresponding":false},{"id":392146,"name":"Javier Apfeld","orcid":"0000-0001-9897-5671","position":14,"is_corresponding":false},{"id":392134,"name":"Jodie A. Schiffer","orcid":"0000-0003-0265-1483","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-18T23:49:43.496702Z","pmid":"34941962","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}