{"doi":"10.1371/journal.ppat.1009805","title":"Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis","abstract":"Tuberculosis (TB) remains a major health problem throughout the world with one third of the population latently infected and ~1.74 million deaths annually. Current therapy consists of multiple antibiotics and a lengthy treatment regimen, which is associated with risk for the generation of drug-resistant Mycobacterium tuberculosis variants. Therefore, alternate host directed strategies that can shorten treatment length and enhance anti-TB immunity during the treatment phase are urgently needed. Here, we show that Luteolin, a plant-derived hepatoprotective immunomodulator, when administered along with isoniazid as potential host directed therapy promotes anti-TB immunity, reduces the length of TB treatment and prevents disease relapse. Luteolin also enhances long-term anti-TB immunity by promoting central memory T cell responses. Furthermore, we found that Luteolin enhances the activities of natural killer and natural killer T cells, both of which exhibit antitubercular attributes. Therefore, the addition of Luteolin to conventional antibiotic therapy may provide a means to avoid the development of drug-resistance and to improve disease outcome.","journal":"PLoS Pathogens","year":2021,"id":171884,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":419898,"name":"Sultan Tousif","orcid":"0000-0001-6174-6541","position":1,"is_corresponding":false},{"id":707292,"name":"Ashima Bhaskar","orcid":"0000-0002-7367-874X","position":2,"is_corresponding":false},{"id":707293,"name":"Annu Devi","orcid":"0000-0002-4481-4175","position":3,"is_corresponding":false},{"id":708071,"name":"Kriti Negi","orcid":null,"position":4,"is_corresponding":false},{"id":707294,"name":"Barnani Moitra","orcid":"0000-0003-1293-9130","position":5,"is_corresponding":false},{"id":708072,"name":"Anand Ranganathan","orcid":null,"position":6,"is_corresponding":false},{"id":707295,"name":"Ved Prakash Dwivedi","orcid":"0000-0003-4321-2567","position":7,"is_corresponding":false},{"id":707296,"name":"Gobardhan Das","orcid":"0000-0003-2713-9558","position":8,"is_corresponding":false},{"id":245261,"name":"Dhiraj Kumar Singh","orcid":"0000-0001-5507-1197","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:37.150824Z","pmid":"34415976","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}