{"doi":"10.1371/journal.ppat.1009691","title":"Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities?","abstract":"Neutrophils are the most abundant innate immune cells in the bloodstream and play critical roles in defending the body against invasive bacterial and fungal infections. While short lived, neutrophils rapidly deploy a variety of mechanisms to eradicate microbial pathogens including phagocytosis, the release of antimicrobial peptides, the production of reactive oxygen species (ROS), the formation of neutrophil extracellular traps (NETs), and the secretion of cytokines and chemokines. Additionally, neutrophils maintain a wide breadth of roles in homeostasis, including the clearance of necrotic tissue, and in disease where they become a source of damaging inflammation Because of this functional plasticity in both homeostasis and infection, neutrophils are hypothesized to exist as unique, diverse subsets of heterogeneous populations of cells.","journal":"PLoS Pathogens","year":2021,"id":197962,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":426963,"name":"Alex Hopke","orcid":"0000-0003-4860-4121","position":1,"is_corresponding":false},{"id":91625,"name":"David B. Sykes","orcid":"0000-0002-9788-0221","position":2,"is_corresponding":false},{"id":426967,"name":"Daniel Irimia","orcid":"0000-0001-7347-2082","position":3,"is_corresponding":false},{"id":89098,"name":"Michael K. Mansour","orcid":"0000-0001-8892-8695","position":4,"is_corresponding":false},{"id":426964,"name":"Allison K. Scherer","orcid":"0000-0003-3735-3873","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-18T23:50:27.616568Z","pmid":"34324592","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}