{"doi":"10.1371/journal.ppat.1009624","title":"Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates","abstract":"A primary goal of HIV-1 vaccine development is the consistent elicitation of protective, neutralizing antibodies. While highly similar neutralizing antibodies (nAbs) have been isolated from multiple HIV-infected individuals, it is unclear whether vaccination can consistently elicit highly similar nAbs in genetically diverse primates. Here, we show in three outbred rhesus macaques that immunization with Env elicits a genotypically and phenotypically conserved nAb response. From these vaccinated macaques, we isolated four antibody lineages that had commonalities in immunoglobulin variable, diversity, and joining gene segment usage. Atomic-level structures of the antigen binding fragments of the two most similar antibodies showed nearly identical paratopes. The Env binding modes of each of the four vaccine-induced nAbs were distinct from previously known monoclonal HIV-1 neutralizing antibodies, but were nearly identical to each other. The similarities of these antibodies show that the immune system in outbred primates can respond to HIV-1 Env vaccination with a similar structural and genotypic solution for recognizing a particular neutralizing epitope. These results support rational vaccine design for HIV-1 that aims to reproducibly elicit, in genetically diverse primates, nAbs with specific paratope structures capable of binding conserved epitopes.","journal":"PLoS Pathogens","year":2021,"id":208312,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":551664,"name":"Wei‐Hung Chen","orcid":"0000-0003-3724-9195","position":1,"is_corresponding":false},{"id":136974,"name":"Weimin Wu","orcid":null,"position":2,"is_corresponding":false},{"id":794874,"name":"Julia A. 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Tomaras","orcid":"0000-0001-8076-1931","position":18,"is_corresponding":false},{"id":268925,"name":"Kshitij Wagh","orcid":"0000-0001-7552-6582","position":19,"is_corresponding":false},{"id":24197,"name":"Bette Korber","orcid":"0000-0002-2026-5757","position":20,"is_corresponding":false},{"id":280548,"name":"Mattia Bonsignori","orcid":"0000-0003-2973-2101","position":21,"is_corresponding":false},{"id":103755,"name":"David C. Montefiori","orcid":"0000-0003-0856-6319","position":22,"is_corresponding":false},{"id":96347,"name":"Barton F. Haynes","orcid":"0000-0002-7643-9023","position":23,"is_corresponding":false},{"id":228429,"name":"Natalia de Val","orcid":"0000-0002-1506-2023","position":24,"is_corresponding":false},{"id":290901,"name":"Michael Joyce","orcid":"0000-0002-6808-7232","position":25,"is_corresponding":false},{"id":230387,"name":"Kevin O. 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