{"doi":"10.1371/journal.ppat.1009339","title":"TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption","abstract":"Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after antiretroviral therapy (ART) interruption. Rhesus macaques inoculated with SHIV-1157ipd3N4 were initiated on daily suppressive ART from Day 14 post SHIV inoculation. Active arm animals (n = 8) received GS-986, N6-LS and PGT121 after plasma viral suppression, starting from week 14. GS-986 induced immune activation and SHIV-specific T cell responses but not viral expression in all the active arm animals. After ART interruption, median time to viral rebound was 6 weeks in the active and 3 weeks in the control arm (p = 0.024). In this animal model, the administration of the combination of GS-986 and dual bnAbs was associated with a modest delay in viral rebound. This strategy should be further evaluated to better understand the underlying mechanisms for the induction of virus-specific immune responses and delay in viral rebound.","journal":"PLoS Pathogens","year":2021,"id":162192,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":347961,"name":"Alexandra Schuetz","orcid":"0000-0003-2829-1340","position":1,"is_corresponding":false},{"id":679401,"name":"Rawiwan Im‐Erbsin","orcid":null,"position":2,"is_corresponding":false},{"id":679402,"name":"Decha Silsorn","orcid":null,"position":3,"is_corresponding":false},{"id":266884,"name":"Amarendra Pegu","orcid":"0000-0003-3564-6453","position":4,"is_corresponding":false},{"id":679403,"name":"Dutsadee Inthawong","orcid":null,"position":5,"is_corresponding":false},{"id":679404,"name":"Jumpol Sopanaporn","orcid":null,"position":6,"is_corresponding":false},{"id":679405,"name":"Pornsuk Visudhiphan","orcid":null,"position":7,"is_corresponding":false},{"id":679406,"name":"Weerawan Chuenarom","orcid":null,"position":8,"is_corresponding":false},{"id":679407,"name":"Boot Keawboon","orcid":null,"position":9,"is_corresponding":false},{"id":105599,"name":"Wei Shi","orcid":"0000-0002-4770-6444","position":10,"is_corresponding":false},{"id":288619,"name":"Merlin L. Robb","orcid":"0000-0003-3949-9649","position":11,"is_corresponding":false},{"id":105614,"name":"John R. Mascola","orcid":"0000-0002-5293-4695","position":12,"is_corresponding":false},{"id":353338,"name":"Romas Geleziunas","orcid":"0000-0002-9290-8811","position":13,"is_corresponding":false},{"id":290824,"name":"Richard A. Koup","orcid":"0000-0002-3090-7282","position":14,"is_corresponding":false},{"id":106527,"name":"Dan H. Barouch","orcid":"0000-0001-5127-4659","position":15,"is_corresponding":false},{"id":40990,"name":"Nelson L. Michael","orcid":"0000-0001-5882-5548","position":16,"is_corresponding":false},{"id":369890,"name":"Sandhya Vasan","orcid":"0000-0002-6378-6288","position":17,"is_corresponding":false},{"id":567471,"name":"Denise C. Hsu","orcid":"0000-0001-7530-0508","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T23:45:00.600065Z","pmid":"33600506","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}