{"doi":"10.1371/journal.ppat.1008994","title":"IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection","abstract":"Inflammation is critical for controlling pathogens, but also responsible for symptoms of infectious diseases. IL-27 is an important regulator of inflammation and can limit development of IFNγ-producing Tbet+ CD4+ T (Th1) cells. IL-27 is thought to do this by stimulating IL-10 production by CD4+ T cells, but the underlying mechanisms of these immunoregulatory pathways are not clear. Here we studied the role of IL-27 signalling in experimental visceral leishmaniasis (VL) caused by infection of C57BL/6 mice with the human pathogen Leishmania donovani. We found IL-27 signalling was critical for the development of IL-10-producing Th1 (Tr1) cells during infection. Furthermore, in the absence of IL-27 signalling, there was improved control of parasite growth, but accelerated splenic pathology characterised by the loss of marginal zone macrophages. Critically, we discovered that IL-27 signalling limited glycolysis in Th1 cells during infection that in turn attenuated inflammation. Furthermore, the modulation of glycolysis in the absence of IL-27 signalling restricted tissue pathology without compromising anti-parasitic immunity. Together, these findings identify a novel mechanism by which IL-27 mediates immune regulation during disease by regulating cellular metabolism.","journal":"PLoS Pathogens","year":2020,"id":97378,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242721,"name":"Fabian de Labastida Rivera","orcid":"0000-0001-5241-2339","position":1,"is_corresponding":false},{"id":482202,"name":"Clay Winterford","orcid":null,"position":2,"is_corresponding":false},{"id":242730,"name":"Teija Frame","orcid":"0000-0002-0937-4231","position":3,"is_corresponding":false},{"id":242720,"name":"Susanna S. Ng","orcid":"0000-0002-8494-7722","position":4,"is_corresponding":false},{"id":242745,"name":"Fiona H. Amante","orcid":"0000-0002-7788-5885","position":5,"is_corresponding":false},{"id":242746,"name":"Chelsea L. Edwards","orcid":"0000-0002-5881-263X","position":6,"is_corresponding":false},{"id":481514,"name":"Luzia Bukali","orcid":"0000-0003-1743-8570","position":7,"is_corresponding":false},{"id":242744,"name":"Yulin Wang","orcid":"0000-0002-9976-5315","position":8,"is_corresponding":false},{"id":242755,"name":"Jude E. Uzonna","orcid":"0000-0003-2759-0664","position":9,"is_corresponding":false},{"id":242726,"name":"Rachel D. Kuns","orcid":"0000-0002-7465-7262","position":10,"is_corresponding":false},{"id":242725,"name":"Ping Zhang","orcid":"0000-0002-0311-6725","position":11,"is_corresponding":false},{"id":261829,"name":"Agnieszka M. Kabat","orcid":"0000-0003-1916-5983","position":12,"is_corresponding":false},{"id":235582,"name":"Ramon I. Klein Geltink","orcid":"0000-0003-4610-3059","position":13,"is_corresponding":false},{"id":235585,"name":"Edward J. Pearce","orcid":"0000-0003-1001-9656","position":14,"is_corresponding":false},{"id":242760,"name":"Geoffrey R. Hill","orcid":"0000-0003-2994-0429","position":15,"is_corresponding":false},{"id":242764,"name":"Christian Engwerda","orcid":"0000-0003-2813-4804","position":16,"is_corresponding":false},{"id":242739,"name":"Marcela Montes de","orcid":"0000-0003-1152-6158","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-18T22:35:34.520494Z","pmid":"33049000","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}