{"doi":"10.1371/journal.ppat.1008570","title":"Biological sex impacts COVID-19 outcomes","abstract":"The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.","journal":"PLoS Pathogens","year":2020,"id":49097,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":295,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235562,"name":"Santosh Dhakal","orcid":"0000-0002-4494-8608","position":1,"is_corresponding":false},{"id":227502,"name":"Rebecca L. Ursin","orcid":"0000-0002-3398-331X","position":2,"is_corresponding":false},{"id":238731,"name":"Sharvari Deshpande","orcid":null,"position":3,"is_corresponding":false},{"id":104961,"name":"Kathryn Sandberg","orcid":"0000-0003-2967-8336","position":4,"is_corresponding":false},{"id":104951,"name":"Franck Mauvais‐Jarvis","orcid":"0000-0002-0874-0754","position":5,"is_corresponding":false},{"id":104954,"name":"Sabra L. Klein","orcid":"0000-0002-0730-5224","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T20:36:25.163232Z","pmid":"32569293","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}