{"doi":"10.1371/journal.pone.0318017","title":"Statins to reduce renal sinus fat among breast cancer patients undergoing anthracycline-based chemotherapy: A substudy of PREVENT-WF-98213","abstract":"OBJECTIVE: To test if statin administration attenuated renal sinus fat (RSF) accumulation and if RSF was associated with renal function in women with breast cancer (BC) receiving anthracycline-based chemotherapy. METHODS: This was a secondary analysis in a subgroup of women with stage I-III BC randomized to placebo (n = 35) or statin (40 mg/day atorvastatin, n = 44) therapy. At baseline and 24-months after randomization, RSF and intraabdominal fat were measured from magnetic resonance images, and estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. RESULTS: Participants in this study averaged 51 years of age (SD 11), 87% reported White race, and had a mean BMI (±SD) of 30.2 kg/m2 (±6.1). Most participants (60%) were diagnosed with stage II BC. At 24-months, RSF was higher in the placebo group relative to the statin group (β [95% CI], p-value: 0.17 [0.009, 0.34], p = 0.04). After adjusting for baseline RSF, this signal remained but was attenuated (β [95% CI], p-value: 0.12 [-0.06, 0.29], p = 0.18). In all participants at baseline and prior to beginning chemotherapy for BC or study drug, higher RSF was associated with lower eGFR values in all participants (r = -0.23, p = 0.03). At 24-months by study group, greater RSF was associated with decreased eGFR in the placebo group (-0.51, p = 0.01) but not in the statin group (-0.25, p = 0.19). DISCUSSION: Statin administration may lower RSF during anthracycline-based chemotherapy. These findings merit further investigation to determine if statins protect renal function during BC treatment.","journal":"PLoS ONE","year":2025,"id":574970,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8709,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":562898,"name":"Nathaniel S. O’Connell","orcid":"0000-0002-3827-5152","position":1,"is_corresponding":false},{"id":304972,"name":"Danielle L. Kirkman","orcid":"0000-0003-1648-0662","position":2,"is_corresponding":false},{"id":366757,"name":"Kristine C. Olson","orcid":"0000-0002-2952-3003","position":3,"is_corresponding":false},{"id":443672,"name":"Kerryn W. Reding","orcid":"0000-0001-5179-8559","position":4,"is_corresponding":false},{"id":282965,"name":"Bonnie Ky","orcid":"0000-0002-6628-9981","position":5,"is_corresponding":false},{"id":274813,"name":"Kathryn J. Ruddy","orcid":"0000-0001-6298-332X","position":6,"is_corresponding":false},{"id":323970,"name":"Glenn J. Lesser","orcid":"0009-0003-5471-8907","position":7,"is_corresponding":false},{"id":43418,"name":"Ralph B. D’Agostino","orcid":"0000-0002-3550-8395","position":8,"is_corresponding":false},{"id":374468,"name":"W. Gregory Hundley","orcid":"0000-0002-2433-8853","position":9,"is_corresponding":false},{"id":338672,"name":"Moriah P. Bellissimo","orcid":"0000-0002-8998-4792","position":10,"is_corresponding":false},{"id":1482997,"name":"William W. Hundley","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:57:44.572630Z","pmid":"40956798","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}