{"doi":"10.1371/journal.pone.0314744","title":"Lower neurovascular coupling response despite higher cerebral blood flow at rest in apolipoprotein ɛ4 positive adults","abstract":"Cerebral blood flow at rest declines with age. However, age-related changes in functional measures of cerebrovascular health including cerebrovascular reactivity and neurovascular coupling are not well understood. Additionally, the effect of apolipoprotein E (APOE) ε4, a strong genetic risk factor for Alzheimer's disease, on cerebral blood flow and cerebrovascular function remains unclear. APOEε4 positive (APOEε4+; n = 37, age = 63±4y) and APOEε4 negative (APOEε4-; n = 50, age = 63±4y) cognitively unimpaired adults participated in this study. Macrovascular cerebral blood flow and microvascular cerebral perfusion were measured using 4D flow MRI and pseudo-continuous arterial spin labeling MRI, respectively. Cerebrovascular reactivity and neurovascular coupling were assessed by measuring middle cerebral artery blood velocity in response to hypercapnia and the n-back test, respectively. Neurovascular coupling was lower in APOEε4+ compared with APOEε4- adults (P<0.05), despite higher cerebral blood flow and cerebrovascular reactivity to hypercapnia. Alterations in neurovascular coupling may occur early, prior to changes in cognition, in aging APOEε4 carriers.","journal":"PLoS ONE","year":2024,"id":462510,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":445018,"name":"Kathleen B. Miller","orcid":"0000-0003-2878-3978","position":1,"is_corresponding":false},{"id":735100,"name":"Adam T. Corkery","orcid":"0000-0003-1657-3025","position":2,"is_corresponding":false},{"id":1077178,"name":"Nicole A. Loggie","orcid":null,"position":3,"is_corresponding":false},{"id":639261,"name":"Anna J. Howery","orcid":null,"position":4,"is_corresponding":false},{"id":389939,"name":"Leonardo A. Rivera‐Rivera","orcid":"0000-0001-5629-8721","position":5,"is_corresponding":false},{"id":416372,"name":"Oliver Wieben","orcid":"0000-0002-7931-1930","position":6,"is_corresponding":false},{"id":313994,"name":"Kevin M. Johnson","orcid":"0000-0002-8660-0853","position":7,"is_corresponding":false},{"id":230038,"name":"Sterling C. Johnson","orcid":"0000-0002-8501-545X","position":8,"is_corresponding":false},{"id":408847,"name":"Jill N. Barnes","orcid":"0000-0001-6317-4153","position":9,"is_corresponding":false},{"id":826968,"name":"Andrew G. Pearson","orcid":"0000-0002-3908-936X","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:04:24.680035Z","pmid":"39625920","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}