{"doi":"10.1371/journal.pone.0313091","title":"Fatty acid binding protein 7 plays an important modulatory sex-dependent role on brain endocannabinoid levels and THC metabolism","abstract":"Fatty acid binding protein 7 (FABP7) is present in the brain, but its interaction with the endocannabinoid system and phytocannabinoids is still not well understood. FABP7 has been proposed as a shuttle protein for trafficking endogenous cannabinoids, as well as an intracellular carrier of THC. In a mouse model of FABP7 global deletion, we used ultra-high performance liquid chromatography- tandem mass spectrometry (UPLC-MS/MS) to measure brain levels of Δ9 tetrahydrocannabinol (THC) as well as its primary metabolite, 11-hydroxy-THC (11-OH-THC), in male and female mice after acute inhalation of THC, compared to wild-type controls. We also measured brain levels of endogenous cannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) both at baseline and after acute THC inhalation. We found that in females, brain concentrations of 11-OH-THC were significantly reduced in FABP7-/- mice compared to FABP7+/+. Additionally, FABP7-/- females had significantly reduced AEA levels and significantly increased 2-AG levels in brain tissue compared to FABP7+/+. Vaporized THC administration had trending, but not significant, impacts on endocannabinoid concentrations in both males and females. Our findings suggest a sex-specific role of FABP7 in the metabolism of THC as well as the regulation of endocannabinoid levels in the brain.","journal":"PLoS ONE","year":2024,"id":458898,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":699013,"name":"Alexandria S. Senetra","orcid":"0000-0001-9571-8426","position":1,"is_corresponding":false},{"id":431447,"name":"Nicole Roeder","orcid":null,"position":2,"is_corresponding":false},{"id":979038,"name":"Brittany Richardson","orcid":"0000-0002-9980-0192","position":3,"is_corresponding":false},{"id":1234733,"name":"Ojas Pareek","orcid":null,"position":4,"is_corresponding":false},{"id":700202,"name":"Yuji Owada","orcid":"0000-0002-5109-0531","position":5,"is_corresponding":false},{"id":1285194,"name":"Yoshiteru Kagawa","orcid":"0000-0003-2963-7905","position":6,"is_corresponding":false},{"id":591864,"name":"Mark S. Gold","orcid":"0000-0003-4713-3751","position":7,"is_corresponding":false},{"id":279431,"name":"Christopher R. McCurdy","orcid":"0000-0001-8695-2915","position":8,"is_corresponding":false},{"id":339817,"name":"Abhisheak Sharma","orcid":"0000-0003-0553-4039","position":9,"is_corresponding":false},{"id":898722,"name":"Panayotis K. Thanos","orcid":"0000-0001-9784-731X","position":10,"is_corresponding":false},{"id":898721,"name":"Samantha Penman","orcid":"0000-0003-3963-6092","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T02:03:50.608887Z","pmid":"39621669","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}