{"doi":"10.1371/journal.pone.0309811","title":"Preferences for oral and injectable PrEP among qualitative sub-study participants in HPTN 084","abstract":"BACKGROUND: HPTN 084 compared the safety and efficacy of long-acting injectable cabotegravir (CAB) to daily oral TDF/FTC for prevention of HIV-1 in uninfected African women. Like a similar trial in MSM/TGW (HPTN 083), the trial was stopped early for efficacy, expediting the need to consider introduction strategies for different populations. We examine survey and qualitative data from a four-country sub-study to examine oral and injectable PrEP acceptability and considerations for CAB access among African women. METHODS: Participants completed baseline and follow-up surveys on HIV risk perception, sexual behavior. product acceptability and adherence during the blinded trial. Additionally, up to two in-depth interviews each with 73 sub-study participants explored product use and trial-related experiences, during the blinded and unblinded study periods. Using survey data, we classified participants as: engaged in female sex work (FSW), having multiple non-transactional partners, or monogamous. A study statistician identified participants' assigned study arm. We followed a thematic analysis process to read transcripts, develop a codebook and apply codes in NVivo to transcripts with intermittent intercoder reliability checks; using Excel matrices to explore differences across risk categories and study arms. FINDINGS: Participants overwhelmingly preferred injections to pills, appreciating the ease, convenience, and privacy of a long-acting formulation. Many participants described challenges with contraceptive and/or study pill adherence, impeded by late night work, unexpected travel, or heavy drinking. Women in the TDF/FTC arm were more likely to describe side effects, compared to those in the CAB arm. Pain also varied widely by study arm. When considering post-trial access to CAB, limited PrEP knowledge, cost and concerns around stigma and poor service quality were potential access barriers. CONCLUSION: Women's desire for privacy and ease of use outweighed injectable concerns, resulting in a strong preference for CAB. Cost and accessibility will need to be addressed by implementation programs.","journal":"PLoS ONE","year":2024,"id":431791,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9359,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":669710,"name":"Agatha Bula","orcid":"0000-0001-8440-7059","position":1,"is_corresponding":false},{"id":492650,"name":"Miria Chitukuta","orcid":"0000-0002-7345-0251","position":2,"is_corresponding":false},{"id":1236458,"name":"Nomhle Ndimande‐Khoza","orcid":null,"position":3,"is_corresponding":false},{"id":473723,"name":"Juliane Etima","orcid":"0000-0002-5879-6000","position":4,"is_corresponding":false},{"id":606906,"name":"Emily Namey","orcid":"0000-0003-3200-1633","position":5,"is_corresponding":false},{"id":773173,"name":"Doreen Kemigisha","orcid":null,"position":6,"is_corresponding":false},{"id":409075,"name":"Lerato M. Makhale","orcid":"0000-0003-0952-6757","position":7,"is_corresponding":false},{"id":670252,"name":"Mercy Tsidya","orcid":null,"position":8,"is_corresponding":false},{"id":1236047,"name":"Marie Shoen","orcid":"0000-0002-3627-7613","position":9,"is_corresponding":false},{"id":312050,"name":"Mina C. Hosseinipour","orcid":"0000-0003-2174-313X","position":10,"is_corresponding":false},{"id":1236459,"name":"Sinead Delany- Moretlwe","orcid":null,"position":11,"is_corresponding":false},{"id":1236460,"name":"on behalf of the HPTN 084 study team","orcid":null,"position":12,"is_corresponding":false},{"id":340354,"name":"Elizabeth E. Tolley","orcid":"0000-0002-9823-3675","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:59:30.747263Z","pmid":"39441777","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}