{"doi":"10.1371/journal.pone.0291657","title":"EquiPrEP: An implementation science protocol for promoting equitable access and uptake of long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP)","abstract":"BACKGROUND: Long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP) was approved by the U.S. Food and Drug Administration in December 2021. This initial phase of implementation represents a prime opportunity to ensure equitable LAI-PrEP provision to communities often underrepresented in PrEP care before disparities in access and uptake emerge. Herein, we describe the EquiPrEP Project which utilizes an equity-oriented implementation science framework to optimize LAI-PrEP rollout in an urban safety-net clinic in New York City. METHODS: The primary objectives of this project are to: (1) increase LAI-PrEP initiation overall; (2) increase uptake among groups disproportionately impacted by the HIV epidemic; (3) preserve high PrEP retention while expanding use; and (4) identify barriers and facilitators to LAI-PrEP use. EquiPrEP will enroll 210 PrEP-eligible participants into LAI-PrEP care with planned follow-up for one year. We will recruit from the following priority populations: Black and/or Latine men who have sex with men, Black and/or Latine cisgender women, and transgender women and nonbinary individuals. To evaluate implementation of LAI-PrEP, we will utilize equity-focused iterations of the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework and the Consolidated Framework for Implementation Research (CFIR), in addition to longitudinal surveys and qualitative interviews. DISCUSSION: Novel LAI-PrEP formulations carry tremendous potential to revolutionize the field of HIV prevention. Implementation strategies rooted in equity are needed to ensure that marginalized populations have access to LAI-PrEP and to address the structural factors that hinder initiation and retention in care.","journal":"PLoS ONE","year":2023,"id":354206,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9623,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1101283,"name":"Brandi E. Moore","orcid":"0000-0001-8613-4170","position":1,"is_corresponding":false},{"id":1101284,"name":"Emma Kaplan‐Lewis","orcid":"0000-0002-6289-1203","position":2,"is_corresponding":false},{"id":1101834,"name":"Eunice Casey","orcid":null,"position":3,"is_corresponding":false},{"id":971357,"name":"Robert Pitts","orcid":"0000-0003-3576-4548","position":4,"is_corresponding":false},{"id":1101835,"name":"Patricia Pagán Pirallo","orcid":null,"position":5,"is_corresponding":false},{"id":480871,"name":"Sahnah Lim","orcid":"0000-0001-7406-5235","position":6,"is_corresponding":false},{"id":579508,"name":"Farzana Kapadia","orcid":"0000-0003-3459-767X","position":7,"is_corresponding":false},{"id":1069373,"name":"Gabriel Cohen","orcid":"0000-0002-8653-4518","position":8,"is_corresponding":false},{"id":425871,"name":"Maria R. Khan","orcid":"0000-0002-6164-7284","position":9,"is_corresponding":false},{"id":1101285,"name":"Ofole Mgbako","orcid":"0000-0002-8955-4303","position":10,"is_corresponding":false},{"id":1099282,"name":"Christina M. Kaul","orcid":"0000-0002-1310-8737","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:13:06.959762Z","pmid":"37725628","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}