{"doi":"10.1371/journal.pone.0288544","title":"Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity","abstract":"Tobacco smoking imposes a staggering burden on public health, underscoring the urgency of developing a deeper understanding of the processes that maintain addiction. Clinical and experience-sampling data highlight the importance of anxious withdrawal symptoms, but the underlying neurobiology has remained elusive. Mechanistic work in animals implicates the central extended amygdala (EAc)-including the central nucleus of the amygdala and the neighboring bed nucleus of the stria terminalis-but the translational relevance of these discoveries remains unexplored. Here we leveraged a randomized trial design, well-established threat-anticipation paradigm, and multidimensional battery of assessments to understand the consequences of 24-hour nicotine abstinence. The threat-anticipation paradigm had the expected consequences, amplifying subjective distress and arousal, and recruiting the canonical threat-anticipation network. Abstinence increased smoking urges and withdrawal symptoms, and potentiated threat-evoked distress, but had negligible consequences for EAc threat reactivity, raising questions about the translational relevance of prominent animal and human models of addiction. These observations provide a framework for conceptualizing nicotine abstinence and withdrawal, with implications for basic, translational, and clinical science.","journal":"PLoS ONE","year":2023,"id":357916,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":876257,"name":"Claire M. Kaplan","orcid":"0000-0003-2753-8225","position":1,"is_corresponding":false},{"id":805712,"name":"Samiha Islam","orcid":"0000-0003-3238-7740","position":2,"is_corresponding":false},{"id":805711,"name":"Allegra S. Anderson","orcid":"0000-0002-0961-9016","position":3,"is_corresponding":false},{"id":410927,"name":"Megan E. Piper","orcid":"0000-0002-9876-5460","position":4,"is_corresponding":false},{"id":858783,"name":"Daniel E. Bradford","orcid":"0000-0003-0920-6964","position":5,"is_corresponding":false},{"id":6158,"name":"John J. Curtin","orcid":"0000-0002-3286-938X","position":6,"is_corresponding":false},{"id":805715,"name":"Kathryn A. DeYoung","orcid":"0000-0002-3904-7979","position":7,"is_corresponding":false},{"id":523322,"name":"Jason F. Smith","orcid":null,"position":8,"is_corresponding":false},{"id":268757,"name":"Andrew S. Fox","orcid":"0000-0003-0695-3323","position":9,"is_corresponding":false},{"id":404785,"name":"Alexander J. Shackman","orcid":"0000-0002-3629-4704","position":10,"is_corresponding":false},{"id":805713,"name":"Hyung Cho Kim","orcid":"0000-0002-1804-1244","position":0,"is_corresponding":true}],"reference_count":129,"raw_metadata":null,"created_at":"2026-07-19T01:13:39.186262Z","pmid":"37471317","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}