{"doi":"10.1371/journal.pone.0287103","title":"Impact of maternal SARS-CoV-2 booster vaccination on blood and breastmilk antibodies","abstract":"Maternal COVID-19 vaccination could protect infants who are ineligible for vaccine through antibody transfer during pregnancy and lactation. We measured the quantity and durability of SARS-CoV-2 antibodies in human milk and infant blood before and after maternal booster vaccination. Prospective cohort of lactating women immunized with primary and booster COVID-19 vaccines during pregnancy or lactation and their infants. Milk and blood samples from October 2021 to April 2022 were included. Anti-nucleoprotein (NP) and anti-receptor binding domain (RBD) IgG and IgA in maternal milk and maternal and infant blood were measured and compared longitudinally after maternal booster vaccine. Forty-five lactating women and their infants provided samples. 58% of women were anti-NP negative and 42% were positive on their first blood sample prior to booster vaccine. Anti-RBD IgG and IgA in milk remained significantly increased through 120-170 days after booster vaccine and did not differ by maternal NP status. Anti-RBD IgG and IgA did not increase in infant blood after maternal booster. Of infants born to women vaccinated in pregnancy, 74% still had positive serum anti-RBD IgG measured on average 5 months after delivery. Infant to maternal IgG ratio was highest for infants exposed to maternal primary vaccine during the second trimester compared to third trimester (0.85 versus 0.29; p<0.001). Maternal COVID-19 primary and booster vaccine resulted in robust and long-lasting transplacental and milk antibodies. These antibodies may provide important protection against SARS-CoV-2 during the first six months of life.","journal":"PLoS ONE","year":2023,"id":372908,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8983,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":956545,"name":"Anthony J. Lentscher","orcid":null,"position":1,"is_corresponding":false},{"id":1122293,"name":"Lingqing Xu","orcid":"0000-0002-6451-1673","position":2,"is_corresponding":false},{"id":500046,"name":"Maris S. Wilkins","orcid":null,"position":3,"is_corresponding":false},{"id":1082336,"name":"Amro Nasser","orcid":null,"position":4,"is_corresponding":false},{"id":1127169,"name":"Dylan J. Tuttle","orcid":"0000-0002-0512-2512","position":5,"is_corresponding":false},{"id":320289,"name":"Christina Megli","orcid":"0000-0002-6579-3908","position":6,"is_corresponding":false},{"id":441635,"name":"Ernesto T. A. Marques","orcid":"0000-0003-3826-9358","position":7,"is_corresponding":false},{"id":218428,"name":"Anita K. McElroy","orcid":"0000-0001-6764-7536","position":8,"is_corresponding":false},{"id":236968,"name":"John V. Williams","orcid":"0000-0001-8377-5175","position":9,"is_corresponding":false},{"id":400370,"name":"Judith M. Martin","orcid":"0000-0001-9456-1770","position":10,"is_corresponding":false},{"id":440244,"name":"Anne-Marie Rick","orcid":"0000-0002-8166-1198","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:15:58.101083Z","pmid":"37310982","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}