{"doi":"10.1371/journal.pone.0283290","title":"Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household","abstract":"BACKGROUND: Understanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting contact investigations. METHODS: Using data from a cross-sectional study that enrolled index participants with rifampin-resistant pulmonary TB and their household contacts (HHCs), we evaluated HHCs age ≥15 years for factors associated with two outcomes: Mycobacterium tuberculosis infection and TB disease. Among HHCs who were not already diagnosed with current active TB disease by the TB program, Mycobacterium tuberculosis infection was determined by interferon-gamma release assay (IGRA). TB disease was adjudicated centrally. We fitted logistic regression models using generalized estimating equations. RESULTS: Seven hundred twelve HHCs age ≥15 years enrolled from 279 households in eight high-TB burden countries were a median age of 34 years, 63% female, 22% current smokers and 8% previous smokers, 8% HIV-positive, and 11% previously treated for TB. Of 686 with determinate IGRA results, 471 tested IGRA positive (prevalence 68.8% (95% Confidence Interval: 64.6%, 72.8%)). Multivariable modeling showed IGRA positivity was more common in HHCs aged 25-49 years; reporting prior TB treatment; reporting incarceration, substance use, and/or a period of daily alcohol use in the past 12 months; sharing a sleeping room or more evenings spent with the index participant; living with smokers; or living in a home of materials typical of low socioeconomic status. Forty-six (6.5% (95% Confidence Interval: 4.6%, 9.0%)) HHCs age ≥15 years had prevalent TB disease. Multivariable modeling showed higher prevalence of TB disease among HHCs aged ≥50 years; reporting current or previous smoking; reporting a period of daily alcohol use in the past 12 months; and reporting prior TB treatment. CONCLUSION: We identified overlapping and distinct characteristics associated with Mycobacterium tuberculosis infection and TB disease that may be useful for those conducting household TB investigations.","journal":"PLoS ONE","year":2023,"id":384722,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9288,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":231911,"name":"Anneke C. 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Sarita Shah","orcid":null,"position":4,"is_corresponding":false},{"id":326394,"name":"Sanjay Gaikwad","orcid":"0000-0002-2411-0373","position":5,"is_corresponding":false},{"id":1152561,"name":"Nishi Kumarasamy","orcid":null,"position":6,"is_corresponding":false},{"id":1152562,"name":"Erika Mitchell","orcid":null,"position":7,"is_corresponding":false},{"id":1089344,"name":"Mey León","orcid":null,"position":8,"is_corresponding":false},{"id":265767,"name":"Paula González","orcid":"0000-0003-0154-0087","position":9,"is_corresponding":false},{"id":503215,"name":"Sharlaa Badal‐Faesen","orcid":"0000-0002-7306-5732","position":10,"is_corresponding":false},{"id":1152563,"name":"Madeleine Lourens","orcid":null,"position":11,"is_corresponding":false},{"id":1152564,"name":"Sandy Nerette","orcid":null,"position":12,"is_corresponding":false},{"id":632166,"name":"Justin Shenje","orcid":"0000-0003-3054-3930","position":13,"is_corresponding":false},{"id":1152565,"name":"Petra De Koker","orcid":null,"position":14,"is_corresponding":false},{"id":1152167,"name":"Supalert Nedsuwan","orcid":"0000-0002-2993-0733","position":15,"is_corresponding":false},{"id":442631,"name":"Lerato Mohapi","orcid":null,"position":16,"is_corresponding":false},{"id":438200,"name":"Unoda Chakalisa","orcid":"0000-0002-5146-0491","position":17,"is_corresponding":false},{"id":1152566,"name":"Rosie Mngqbisa","orcid":null,"position":18,"is_corresponding":false},{"id":1152567,"name":"Rodrigo Escada","orcid":null,"position":19,"is_corresponding":false},{"id":361301,"name":"Samuel Gurrion Ouma","orcid":"0000-0003-3559-9028","position":20,"is_corresponding":false},{"id":605543,"name":"Barbara Heckman","orcid":"0000-0002-2289-7387","position":21,"is_corresponding":false},{"id":613678,"name":"Linda Naini","orcid":null,"position":22,"is_corresponding":false},{"id":326405,"name":"Amita Gupta","orcid":"0000-0001-7036-2718","position":23,"is_corresponding":false},{"id":346886,"name":"Susan Swindells","orcid":"0000-0001-5826-6037","position":24,"is_corresponding":false},{"id":432140,"name":"Gavin Churchyard","orcid":"0000-0002-4269-3699","position":25,"is_corresponding":false},{"id":1152568,"name":"on behalf of the ACTG A5300/IMPAACT 2003 PHOENIx Feasibility Study Team","orcid":null,"position":26,"is_corresponding":false},{"id":299149,"name":"Soyeon Kim","orcid":"0000-0002-4776-6092","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:17:37.110513Z","pmid":"36930628","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}