{"doi":"10.1371/journal.pone.0278658","title":"The Utilisation of INR to identify coagulopathy in burn patients","abstract":"Studies conflict on the significance of burn-induced coagulopathy. We posit that burn-induced coagulopathy is associated with injury severity in burns. Our purpose was to characterize coagulopathy profiles in burns and determine relationships between % total burn surface area (TBSA) burned and coagulopathy using the International Normalized Ratio (INR). Burned patients with INR values were identified in the TriNetX database and analyzed by %TBSA burned. Patients with history of transfusions, chronic hepatic failure, and those on anticoagulant medications were excluded. Interquartile ranges for INR in the burned study population were 1.2 (1.0-1.4). An INR of ≥ 1.5 was used to represent those with burn-induced coagulopathy as it fell outside the 3rd quartile. The population was stratified into subgroups using INR levels <1.5 or ≥1.5 on the day of injury. Data are average ± SD analyzed using chi-square; p < .05 was considered significant. There were 7,364 burned patients identified with INR <1.5, and 635 had INR ≥1.5. Comparing TBSA burned groups, burn-induced coagulopathy significantly increased in those with ≥20% TBSA; p = .048 at 20-29% TBSA, p = .0005 at 30-39% TBSA, and p < .0001 for 40% TBSA and above. Age played a significant factor with average age for those with burn-induced coagulopathy 59 ± 21.5 years and 46 ± 21.8 for those without (p < .0001). After matching for age, TBSA, and demographics, the risk of 28 day-mortality was higher in those with burn-induced coagulopathy compared to those without (risk difference 20.9%, p < .0001) and the odd ratio with 95% CI is 4.45 (3.399-5.825). Investigation of conditions associated with burn-induced coagulopathy showed the effect of heart diseases to be significant; 53% of patients with burn-induced coagulopathy had hypertension (p < .0001). Burn-induced coagulopathy increases with %TBSA burned. The information gained firmly reflects a link between %TBSA and burn-induced coagulopathy, which could be useful in prognosis and treatment decisions.","journal":"PLoS ONE","year":2024,"id":448345,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905250,"name":"Juquan Song","orcid":"0000-0002-9371-9078","position":1,"is_corresponding":false},{"id":909416,"name":"Sunny Gotewal","orcid":"0000-0003-3545-5999","position":2,"is_corresponding":false},{"id":1045621,"name":"Lyndon G Huang","orcid":"0000-0001-9333-4808","position":3,"is_corresponding":false},{"id":1045617,"name":"Kassandra K Corona","orcid":"0000-0003-1309-4862","position":4,"is_corresponding":false},{"id":1097263,"name":"Shelby P Bagby","orcid":null,"position":5,"is_corresponding":false},{"id":1045620,"name":"Elvia L Villarreal","orcid":"0009-0002-1630-9021","position":6,"is_corresponding":false},{"id":1096704,"name":"Shivan N Chokshi","orcid":"0000-0001-8912-105X","position":7,"is_corresponding":false},{"id":1046041,"name":"Tsola A Efejuku","orcid":null,"position":8,"is_corresponding":false},{"id":1097262,"name":"Jasmine M Chaij","orcid":null,"position":9,"is_corresponding":false},{"id":1045619,"name":"Alejandro A Joglar","orcid":"0000-0003-2431-6862","position":10,"is_corresponding":false},{"id":380719,"name":"Nicholas J. Iglesias","orcid":"0000-0002-5935-997X","position":11,"is_corresponding":false},{"id":1045618,"name":"Phillip H Keys","orcid":"0000-0001-7544-179X","position":12,"is_corresponding":false},{"id":1045616,"name":"Giovanna De La Tejera","orcid":"0000-0002-9559-3456","position":13,"is_corresponding":false},{"id":275501,"name":"George Golovko","orcid":"0000-0003-4609-2767","position":14,"is_corresponding":false},{"id":473501,"name":"Amina El Ayadi","orcid":"0000-0002-3657-0633","position":15,"is_corresponding":false},{"id":542288,"name":"Steven E. 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